Study of Sacituzumab Govitecan Combinations in First-line Treatment of Participants With Advanced or Metastatic Non-Small-Cell Lung Cancer (NSCLC)

Korábbi kezelés

• NSCLC that is eligible for definitive local therapy alone
• Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy
• Has had an allogenic tissue/solid organ transplant.
• Has received radiation therapy to the lung
• Individuals may not have received systemic anticancer treatment within the previous 6 months
• Is currently participating in or has participated in a study of an investigational agent

Más betegség

• Active second malignancy
• Has an active autoimmune disease that has required systemic treatment in past 2 years
• Has severe (≥ Grade 3) hypersensitivity to SG, pembrolizumab, carboplatin, or cisplatin, their metabolites, or formulation excipient
• Clinically severe pulmonary compromise resulting from intercurrent pulmonary illnesses
• History of cardiac disease
• Active chronic inflammatory bowel disease
• Active serious infection requiring antibiotics
• Active or chronic hepatitis B infection
• Positive hepatitis C antibody

Laborértékek

• Positive serum pregnancy test or women who are lactating
  • Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Egyéb

• Mixed SCLC and NSCLC histology
• Known active central nervous system (CNS) metastases

• Individuals with pathologically documented evidence of Stage IV non-small cell lung Cancer (NSCLC) disease at the time of enrollment
• Measurable disease by computed tomography (CT) or magnetic resonance imaging (MRI) as per RECIST Version 1.1 criteria by investigator
• No prior systemic treatment for metastatic NSCLC
• Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1
• Adequate hematologic counts
• Adequate hepatic function