Parasympathetic Augmentation Via Respiratory Training for Patients With Systolic Heart Failure
Megadott ok: Enrollment goal was not reached within the allotted funding period.
A legfontosabb adatok
- Hol
- Lancaster (Egyesült Államok)A helyszín megnézése
Helyszínek itt: Egyesült Államok
- Lancaster General HospitalLancaster, Egyesült ÁllamokNo longer taking part
A vizsgálat adatai
- Ki végzi
- Lancaster General Hospital
- Azonosító
- NCT05223751
- A regiszteradat frissítve
- 2025. október 23.
- Eredeti leírás
This is a prospective, randomized, controlled clinical trial in which participants with NYHA class II or III and symptomatic Heart Failure with reduced Ejection Fraction (HFrEF) (Ejection Fraction (EF) ≤ 45%) will be assigned to one of two treatment groups: standard of care or breathing therapy.A teljes eredeti leírásKevesebb
This is a prospective, randomized, controlled clinical trial in which participants with NYHA class II or III and symptomatic Heart Failure with reduced Ejection Fraction (HFrEF) (Ejection Fraction (EF) ≤ 45%) will be assigned to one of two treatment groups: standard of care or breathing therapy.
Bevonási feltételek: 18 years or older; Signed informed consent; NYHA class II-III heart failure; EF ≤ 45% (echo within 1 year of enrollment); At least 30 days of stable medical regimen (no new neurohormonal blockade or Sodium-glucose co-transporter 2 inhibitors (SGLT2i). Dose adjustments allowed); Likely to be compliant with breath training as assessed by the provider; Availability of a "smart" phone and internet access; Established care at Lancaster General Health Penn Medicine.
Kizáró feltételek: Prior or planned chest/abdominal or nasal/facial surgery within 6 months; Cardiac resynchronization therapy (CRT) within 6 months; Severe Chronic obstructive pulmonary disease (COPD); History of diaphragm paralysis; Decompensated or American College of Cardiology (ACC) Stage D Heart Failure (HF); Neuromuscular disease which impairs respiration; Diagnosed cognitive impairment (unable to participate in training); Severe valvular heart disease; Uncontrolled atrial fibrillation (Ave Heart Rate (HR) > 100 bpm); Unable or unwilling to complete respiratory training protocol; Untreated obstructive severe sleep apnea (AHI > 30); Orthopedic or other limitations which impair the 6-minute walk test.