The Safety and Feasibility of Costal Bone Marrow Aspiration During Thoracic Surgery
Megadott ok: Initial observations suggest challenges in performing bone marrow aspiration in the first few patients enrolled in the study.
Key facts
- Where
- Jette, BelgiumSee the site
Where in Belgium
- UZ BrusselJette, BelgiumNo longer taking part
Trial details
- Who runs it
- Universitair Ziekenhuis Brussel
- Trial code
- NCT05251805
- Record updated
- 2025. június 8.
- Original description
This pilot trial is designed to evaluate the feasibility and safety of obtaining bone marrow from costal aspiration during surgery.Read full original descriptionShow less
Phase I Clinical Trial Evaluating the Safety and Feasibility of Bone Marrow Aspiration From Ribs During Thoracic Surgery
This pilot trial is designed to evaluate the feasibility and safety of obtaining bone marrow from costal aspiration during surgery.
The investigators hypothese that sufficient bone marrow-derived HSPC's (which represent only 0,1% of the total bone marrow fraction) can be derived by rib bone marrow aspiration for ex vivo single-cell evaluation, optimization of a 3D BMN platform and preclinical ex/in vivo assessment in patient-derived organoids and murine xenograft models.
Inclusion: Patient undergoing thoracic surgery for a confirmed or suspected lung cancer.
Exclusion: Bleeding disorders; Uncertainty of pre-operative diagnosis, exception is per-op frozen section analysis confirming malignity; ASA ≥ 3.