Marker for Stroke Recovery
Megadott ok: Insufficient personnel dedication.
Key facts
- Where
- Chicago, Egyesült ÁllamokSee the site
Where in Egyesült Államok
- Shirley Ryan AbilityLabChicago, Egyesült ÁllamokNo longer taking part
Trial details
- Who runs it
- Shirley Ryan AbilityLab
- Trial code
- NCT05256368
- Record updated
- 2023. június 1.
- Original description
This study aims to develop a neurophysiological marker for post-stroke participants that predicts upper extremity motor recovery in response to a standard upper extremity rehabilitation protocol of task-specific training (TST). For this aim, the researchers will utilize transcranial magnetic stimulation (TMS) combined with electromyography (EMG) and electroencephalography (EEG) to observe inpatients with stroke-related hemiplegia and follow their recovery through outpatient for up to 3 months. Motor-evoked potentials (MEPs), transcranial-evoked potentials (TEPs), action research arm test (ARAT) scores, and clinical outcome measures will be recorded at different time points of the inpatient rehabilitation period. The researchers hypothesize that changes in motor recovery will be reflected in changes in the MEPs and TEPs.Read full original descriptionShow less
Neurophysiological Marker for Predicting Upper Extremity Motor Recovery After Stroke
This study aims to develop a neurophysiological marker for post-stroke participants that predicts upper extremity motor recovery in response to a standard upper extremity rehabilitation protocol of task-specific training (TST). For this aim, the researchers will utilize transcranial magnetic stimulation (TMS) combined with electromyography (EMG) and electroencephalography (EEG) to observe inpatients with stroke-related hemiplegia and follow their recovery through outpatient for up to 3 months. Motor-evoked potentials (MEPs), transcranial-evoked potentials (TEPs), action research arm test (ARAT) scores, and clinical outcome measures will be recorded at different time points of the inpatient rehabilitation period. The researchers hypothesize that changes in motor recovery will be reflected in changes in the MEPs and TEPs.
Inclusion: Age from 18 to 80 years; Stroke (ischemic subcortical, intermediate level, chronic phase one day to 6 weeks or more from lesion); Clinical and radiological evidence supporting the above diagnoses; Chedoke stroke assessment arm stage and hand stage of 3-6 for the affected limb; One or more behavioral symptoms possibly linked to the white matter lesion(s); Stable medical condition; Normal hearing and (corrected) vision; Able to understand and give informed consent; English speaker.
Exclusion: Surgical clips in the head or previous neurosurgery; Cochlear implants; Non prescribed drug use; Cardiac pacemaker or pacemaker wires; neurostimulators; implanted pumps; Prosthetic heart valves; Epilepsy or any other type of seizure history; History of significant head trauma (i.e., extended loss of consciousness, neurological sequelae); Significant other disease (heart disease, malignant tumors, mental disorders); Significant claustrophobia; Meniere's disease; Medications increasing risk for seizures; Failure to perform the behavioral tasks or neuropsychological evaluation tests; Metal in the body (rods, plates, screws, shrapnel, dentures, IUD) or metallic particles in the eye; Any magnetic particles in the body; Pregnancy, breast feeding; Prisoners.