MRD-guided Adjuvant Tislelizumab and Chemotherapy in Resected Stage IIA-IIIB NSCLC

Korábbi kezelés

• The patient has received immune checkpoint inhibitors such as anti-PD-1, PD-L1 or CTLA-4, other immunotherapy or systemic immune modulators (including but not limited to interferon, IL-2 and TNF etc).
• At the start of the study treatment, there are residual toxicities of the previous treatment that are greater than CTCAE 1 and have not been alleviated, except for alopecia and grade 2 neurotoxicity caused by previous chemotherapy.

Más betegség

• Any serious or uncontrolled systemic disease, including uncontrolled high blood pressure, active bleeding, active infection including hepatitis B, C, HIV, etc., which the investigator considers unsuitable to participate in the study or affect the trial program compliance.
• History of ILD, drug-induced interstitial lung disease, radiation pneumonitis requiring steroid therapy, or any evidence of clinically active interstitial lung disease
• History of hypersensitivity reactions to any active or inactive ingredient of tislelizumab or to drugs that are chemically similar to tislelizumab or in the same class of tislelizumab.
• Patients who, in the investigator's judgment, have any condition that compromises patient safety or interferes with the evaluation of the study.

Laborértékek

• Harboring EGFR sensitizing mutation or ALK gene translocation

Életkor

• History of other malignant tumors, except for non-melanoma skin cancer, carcinoma in situ or other solid tumors that have been effectively treated, and no evidence of any disease for >5 years after the last treatment.

Egyéb

• Histopathology with small cell or large cell endocrine tumor component.
• Insufficient bone marrow reserve or organ function.
• Patients who, in the judgment of the investigator, may not comply with the procedures and requirements of the study.

• Patient with age ≥ 18 years old, gender is not limited.
• Histologically confirmed primary NSCLC, postoperative stage is IIA, IIB, IIIA or T3N2IIIB.
• Receiving complete resection
• Paraffin-embedded sections (10-15 pieces) or fresh frozen tissue are required.
• ECOG score of 0 or 1.
• Females of childbearing age should take appropriate contraceptive measures from screening to 3 months after discontinuation of study treatment and should not breastfeed. The pregnancy test was negative before starting dosing.
• Male patients should use barrier contraception from screening to 3 months after discontinuation of study treatment.
• The subjects themselves participated voluntarily and signed the informed consent in writing.