GPC3-targeting CART Cell in Treatment of Advanced Hepatocellular Carcinoma
Megadott ok: achieve the proof of concept
Key facts
- Where
- Beijing, KínaSee the 2 sites
- Phase
- 1. fázis
Where in Kína
- Beijing Gobroad Boren HospitalBeijing, KínaNo longer taking part
- Chinese PLA General HospitalBeijing, KínaNo longer taking part
Trial details
- Who runs it
- jianming xu
- Trial code
- NCT05352542
- Record updated
- 2024. augusztus 9.
- Original description
A Phase I Clinical Trial for Evaluating the Safety, Tolerance and Efficacy of GPC3-targeting CART Cell in Treatment of Advanced Hepatocellular CarcinomaRead full original descriptionShow less
A Phase I Clinical Trial for Evaluating the Safety, Tolerance and Efficacy of GPC3-targeting CART Cell in Treatment of Advanced Hepatocellular Carcinoma
A Phase I Clinical Trial for Evaluating the Safety, Tolerance and Efficacy of GPC3-targeting CART Cell in Treatment of Advanced Hepatocellular Carcinoma
Inclusion: Subjects have fully understood the possible risks and benefits of participating in this study, are willing to follow and able to complete all trial procedures, and have signed informed consent; Age 18-75 years; Patients diagnosed as advanced hepatocellular carcinoma (HCC) histopathologically or cytologically; Progression or intolerance after previous standard systemic therapy; GPC3 is detected positive by immunohistochemistry (IHC); Child-Pugh score ≤ 7; At least one assessable tumor lesion; ECOG score: 0-1; Expected survival ≥ 3 months; Clinical laboratory values meet screening visit criteria.
Exclusion: Previous CAR-T cell, TCR-T cell or other cell therapies or therapeutic tumor vaccination directed at any target; Any previous GPC3 targeted therapy; Prior antitumor therapy with insufficient washout period; HCV-Ab or/and HIV-Ab positive; active syphilis; Severe underlying diseases; Any condition that, in the opinion of the investigator, will make the subject unsuitable for participation in this study; Brain metastases with central nervous system symptoms; Pregnant or lactating women.