Testing the Use of Targeted Treatment for RET Positive Advanced Non-small Cell Lung Cancer
Megadott ok: lack of accrual
Key facts
- Where
- Albuquerque, Altoona, Anaconda, Anaheim, Ann Arbor, Asheville, Ashland, Auburn, Baldwin Park, Barrington, Battle Creek, Beaver, Bellflower, Bemidji, Berkeley, Billings, Bismarck, Bloomington, Boiling Springs, Boise, Bozeman, Brainerd, Brighton, Burlington, Butler, Caldwell, Camp Hill, Canton, Cape Girardeau, Carlisle, Carthage, Centerville, Centralia, Chambersburg, Charleston, Chelsea, Chicago, Cleveland, Clyde, Coeur d'Alene, Collierville, Columbus, Concord, Coon Rapids, Cranberry Township, Crystal Lake, Cumberland, Danville, Dayton, Decatur, Deer River, DeKalb, Des Moines, Detroit, Dixon, Downers Grove, Duluth, Easley, East China Township, Edina, Effingham, Elgin, Ephrata, Erie, Eureka, Fargo, Farmington, Farrell, Flint, Fontana, Franklin, Fremont, Fruitland, Galesburg, Geneva, Germantown, Gettysburg, Grafton, Grand Rapids, Great Falls, Green Bay, Greensburg, Greenville, Greer, Grenada, Grosse Pointe Woods, Harbor City, Harrisburg, Hays, Hazel Crest, Hendersonville, Hibbing, Indiana, Irvine, Johnstown, Jonesboro, Kalamazoo, Kalispell, Kansas City, Kenosha, Kewanee, La Crosse, Lake Forest, Lansing, Las Vegas, Lawrence, Lebanon, Lee's Summit, Lexington, Libertyville, Little Rock, Livonia, Loma Linda, Los Angeles, Macomb, Manchester, Mansfield, Marinette, Mattoon, Mayfield Heights, McKeesport, Mechanicsburg, Memphis, Meridian, Miami Beach, Milwaukee, Minneapolis, Missoula, Monroeville, Moon Township, Moorestown, Muskegon, N. Huntingdon, Nampa, Natrona Heights, New Albany, New Castle, North Kansas City, Norton Shores, O'Fallon, Oak Lawn, Olathe, Ontario, Oshkosh, Ottawa, Overland Park, Oxford, Palo Alto, Panorama City, Park Ridge, Pekin, Peoria, Peru, Pittsburgh, Portland, Post Falls, Princeton, Racine, Reed City, Riverside, Rochester, Roseville, Sacramento, Saint Joseph, Saint Louis Park, Saint Paul, Sainte Genevieve, Salina, San Diego, San Francisco, San Marcos, Sandpoint, Sandstone, Sandusky, Seneca, Sheboygan, Sioux Falls, Southhaven, Springfield, St Louis, St. Helena, Sterling Heights, Steubenville, Strongsville, Sullivan, Summit, Sunset Hills, Sunnyvale, Sylvania, Tampa, Topeka, Traverse City, Troy, Twin Falls, Two Rivers, Uniontown, Urbana, Vallejo, Virginia, Voorhees Township, Warren, Warrensville Heights, Warrenville, Washington, Wauwatosa, Weaverville, West Allis, West Mifflin, Westwood, Whittier, Woodland Hills, Wooster, Wyoming, York és Ypsilanti, Egyesült ÁllamokSee the 265 sites
- Phase
- 2. fázis
Where in Egyesült Államok
- University of New Mexico Cancer CenterAlbuquerque, Egyesült ÁllamokNo longer taking part
- UPMC AltoonaAltoona, Egyesült ÁllamokNo longer taking part
- Community Hospital of AnacondaAnaconda, Egyesült ÁllamokNo longer taking part
- Kaiser Permanente-AnaheimAnaheim, Egyesült ÁllamokNo longer taking part
- Saint Joseph Mercy HospitalAnn Arbor, Egyesült ÁllamokNo longer taking part
- AdventHealth Infusion Center AshevilleAsheville, Egyesült ÁllamokNo longer taking part
- Duluth Clinic AshlandAshland, Egyesült ÁllamokNo longer taking part
- Sutter Auburn Faith HospitalAuburn, Egyesült ÁllamokNo longer taking part
- Kaiser Permanente-Baldwin ParkBaldwin Park, Egyesült ÁllamokNo longer taking part
- Advocate Good Shepherd HospitalBarrington, Egyesült ÁllamokNo longer taking part
- Bronson Battle CreekBattle Creek, Egyesült ÁllamokNo longer taking part
- UPMC-Heritage Valley Health System BeaverBeaver, Egyesült ÁllamokNo longer taking part
- Kaiser Permanente-BellflowerBellflower, Egyesült ÁllamokNo longer taking part
- Sanford Joe Lueken Cancer CenterBemidji, Egyesült ÁllamokNo longer taking part
- Alta Bates Summit Medical Center-Herrick CampusBerkeley, Egyesült ÁllamokNo longer taking part
- Billings Clinic Cancer CenterBillings, Egyesült ÁllamokNo longer taking part
- Sanford Bismarck Medical CenterBismarck, Egyesült ÁllamokNo longer taking part
- Illinois CancerCare-BloomingtonBloomington, Egyesült ÁllamokNo longer taking part
- Prisma Health Cancer Institute - SpartanburgBoiling Springs, Egyesült ÁllamokNo longer taking part
- Saint Alphonsus Cancer Care Center-BoiseBoise, Egyesült ÁllamokNo longer taking part
- Saint Luke's Cancer Institute - BoiseBoise, Egyesült ÁllamokNo longer taking part
- Bozeman Deaconess HospitalBozeman, Egyesült ÁllamokNo longer taking part
- Essentia Health Saint Joseph's Medical CenterBrainerd, Egyesült ÁllamokNo longer taking part
- Saint Joseph Mercy BrightonBrighton, Egyesült ÁllamokNo longer taking part
- Trinity Health IHA Medical Group Hematology Oncology - BrightonBrighton, Egyesült ÁllamokNo longer taking part
- Aurora Cancer Care-Southern Lakes VLCCBurlington, Egyesült ÁllamokNo longer taking part
- UPMC Hillman Cancer Center at Butler Health SystemButler, Egyesült ÁllamokNo longer taking part
- Saint Alphonsus Cancer Care Center-CaldwellCaldwell, Egyesült ÁllamokNo longer taking part
- UPMC Camp HillCamp Hill, Egyesült ÁllamokNo longer taking part
- Aultman Health FoundationCanton, Egyesült ÁllamokNo longer taking part
- Illinois CancerCare-CantonCanton, Egyesült ÁllamokNo longer taking part
- Saint Joseph Mercy CantonCanton, Egyesült ÁllamokNo longer taking part
- Trinity Health IHA Medical Group Hematology Oncology - CantonCanton, Egyesült ÁllamokNo longer taking part
- Saint Francis Medical CenterCape Girardeau, Egyesült ÁllamokNo longer taking part
- Carlisle Regional Cancer CenterCarlisle, Egyesült ÁllamokNo longer taking part
- Illinois CancerCare-CarthageCarthage, Egyesült ÁllamokNo longer taking part
- Miami Valley Hospital SouthCenterville, Egyesült ÁllamokNo longer taking part
- Centralia Oncology ClinicCentralia, Egyesült ÁllamokNo longer taking part
- WellSpan Medical Oncology and HematologyChambersburg, Egyesült ÁllamokNo longer taking part
- Medical University of South CarolinaCharleston, Egyesült ÁllamokNo longer taking part
- Ralph H. Johnson VA Medical CenterCharleston, Egyesült ÁllamokNo longer taking part
- Saint Joseph Mercy ChelseaChelsea, Egyesült ÁllamokNo longer taking part
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea HospitalChelsea, Egyesült ÁllamokNo longer taking part
- Advocate Illinois Masonic Medical CenterChicago, Egyesült ÁllamokNo longer taking part
- Northwestern UniversityChicago, Egyesült ÁllamokNo longer taking part
- Cleveland Clinic Cancer Center/Fairview HospitalCleveland, Egyesült ÁllamokNo longer taking part
- Cleveland Clinic FoundationCleveland, Egyesült ÁllamokNo longer taking part
- AdventHealth Infusion Center HaywoodClyde, Egyesült ÁllamokNo longer taking part
- Kootenai Health - Coeur d'AleneCoeur d'Alene, Egyesült ÁllamokNo longer taking part
- Baptist Memorial Hospital and Cancer Center-ColliervilleCollierville, Egyesült ÁllamokNo longer taking part
- Baptist Memorial Hospital and Cancer Center-Golden TriangleColumbus, Egyesült ÁllamokNo longer taking part
- New Hampshire Oncology Hematology PA-ConcordConcord, Egyesült ÁllamokNo longer taking part
- Mercy HospitalCoon Rapids, Egyesült ÁllamokNo longer taking part
- UPMC Hillman Cancer Center - Passavant - CranberryCranberry Township, Egyesült ÁllamokNo longer taking part
- AMG Crystal Lake - OncologyCrystal Lake, Egyesült ÁllamokNo longer taking part
- UPMC Western MarylandCumberland, Egyesült ÁllamokNo longer taking part
- Carle on VermilionDanville, Egyesült ÁllamokNo longer taking part
- Miami Valley HospitalDayton, Egyesült ÁllamokNo longer taking part
- Miami Valley Hospital NorthDayton, Egyesült ÁllamokNo longer taking part
- Cancer Care Specialists of Illinois - DecaturDecatur, Egyesült ÁllamokNo longer taking part
- Decatur Memorial HospitalDecatur, Egyesült ÁllamokNo longer taking part
- Essentia Health - Deer River ClinicDeer River, Egyesült ÁllamokNo longer taking part
- Northwestern Medicine Cancer Center KishwaukeeDeKalb, Egyesült ÁllamokNo longer taking part
- Mercy Medical Center - Des MoinesDes Moines, Egyesült ÁllamokNo longer taking part
- Ascension Saint John HospitalDetroit, Egyesült ÁllamokNo longer taking part
- Illinois CancerCare-DixonDixon, Egyesült ÁllamokNo longer taking part
- Advocate Good Samaritan HospitalDowners Grove, Egyesült ÁllamokNo longer taking part
- Essentia Health Cancer CenterDuluth, Egyesült ÁllamokNo longer taking part
- Prisma Health Cancer Institute - EasleyEasley, Egyesült ÁllamokNo longer taking part
- Great Lakes Cancer Management Specialists-Doctors ParkEast China Township, Egyesült ÁllamokNo longer taking part
- Fairview Southdale HospitalEdina, Egyesült ÁllamokNo longer taking part
- Carle Physician Group-EffinghamEffingham, Egyesült ÁllamokNo longer taking part
- Crossroads Cancer CenterEffingham, Egyesült ÁllamokNo longer taking part
- Advocate Sherman HospitalElgin, Egyesült ÁllamokNo longer taking part
- Ephrata Cancer CenterEphrata, Egyesült ÁllamokNo longer taking part
- UPMC Hillman Cancer Center ErieErie, Egyesült ÁllamokNo longer taking part
- Illinois CancerCare-EurekaEureka, Egyesült ÁllamokNo longer taking part
- Essentia Health Cancer Center-South University ClinicFargo, Egyesült ÁllamokNo longer taking part
- Sanford Broadway Medical CenterFargo, Egyesült ÁllamokNo longer taking part
- Sanford Roger Maris Cancer CenterFargo, Egyesült ÁllamokNo longer taking part
- Parkland Health Center - FarmingtonFarmington, Egyesült ÁllamokNo longer taking part
- UPMC Cancer Center at UPMC HorizonFarrell, Egyesült ÁllamokNo longer taking part
- Genesee Cancer and Blood Disease Treatment CenterFlint, Egyesült ÁllamokNo longer taking part
- Genesee Hematology Oncology PCFlint, Egyesült ÁllamokNo longer taking part
- Genesys Hurley Cancer InstituteFlint, Egyesült ÁllamokNo longer taking part
- Hurley Medical CenterFlint, Egyesült ÁllamokNo longer taking part
- Kaiser Permanente-FontanaFontana, Egyesült ÁllamokNo longer taking part
- Atrium Medical Center-Middletown Regional HospitalFranklin, Egyesült ÁllamokNo longer taking part
- Palo Alto Medical Foundation-FremontFremont, Egyesült ÁllamokNo longer taking part
- Saint Luke's Cancer Institute - FruitlandFruitland, Egyesült ÁllamokNo longer taking part
- Illinois CancerCare-GalesburgGalesburg, Egyesült ÁllamokNo longer taking part
- Northwestern Medicine Cancer Center DelnorGeneva, Egyesült ÁllamokNo longer taking part
- Aurora Health Care Germantown Health CenterGermantown, Egyesült ÁllamokNo longer taking part
- Adams Cancer CenterGettysburg, Egyesült ÁllamokNo longer taking part
- Aurora Cancer Care-GraftonGrafton, Egyesült ÁllamokNo longer taking part
- Spectrum Health at Butterworth CampusGrand Rapids, Egyesült ÁllamokNo longer taking part
- Benefis Healthcare- Sletten Cancer InstituteGreat Falls, Egyesült ÁllamokNo longer taking part
- Aurora BayCare Medical CenterGreen Bay, Egyesült ÁllamokNo longer taking part
- UPMC Cancer Centers - Arnold Palmer PavilionGreensburg, Egyesült ÁllamokNo longer taking part
- Oncology Hematology AssociatesGreenville, Egyesült ÁllamokNo longer taking part
- Prisma Health Cancer Institute - ButternutGreenville, Egyesült ÁllamokNo longer taking part
- Prisma Health Cancer Institute - EastsideGreenville, Egyesült ÁllamokNo longer taking part
- Prisma Health Cancer Institute - FarisGreenville, Egyesült ÁllamokNo longer taking part
- Prisma Health Greenville Memorial HospitalGreenville, Egyesült ÁllamokNo longer taking part
- Prisma Health Cancer Institute - GreerGreer, Egyesült ÁllamokNo longer taking part
- Baptist Cancer Center-GrenadaGrenada, Egyesült ÁllamokNo longer taking part
- Academic Hematology Oncology SpecialistsGrosse Pointe Woods, Egyesült ÁllamokNo longer taking part
- Great Lakes Cancer Management Specialists-Van Elslander Cancer CenterGrosse Pointe Woods, Egyesült ÁllamokNo longer taking part
- Kaiser Permanente - Harbor CityHarbor City, Egyesült ÁllamokNo longer taking part
- UPMC Pinnacle Cancer Center/Community Osteopathic CampusHarrisburg, Egyesült ÁllamokNo longer taking part
- HaysMed University of Kansas Health SystemHays, Egyesült ÁllamokNo longer taking part
- Advocate South Suburban HospitalHazel Crest, Egyesült ÁllamokNo longer taking part
- AdventHealth HendersonvilleHendersonville, Egyesült ÁllamokNo longer taking part
- Essentia Health Hibbing ClinicHibbing, Egyesült ÁllamokNo longer taking part
- IRMC Cancer CenterIndiana, Egyesült ÁllamokNo longer taking part
- Kaiser Permanente-IrvineIrvine, Egyesült ÁllamokNo longer taking part
- UPMC-Johnstown/John P. Murtha Regional Cancer CenterJohnstown, Egyesült ÁllamokNo longer taking part
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - JonesboroJonesboro, Egyesült ÁllamokNo longer taking part
- Bronson Methodist HospitalKalamazoo, Egyesült ÁllamokNo longer taking part
- West Michigan Cancer CenterKalamazoo, Egyesült ÁllamokNo longer taking part
- Kalispell Regional Medical CenterKalispell, Egyesült ÁllamokNo longer taking part
- Truman Medical CentersKansas City, Egyesült ÁllamokNo longer taking part
- University of Kansas Cancer CenterKansas City, Egyesült ÁllamokNo longer taking part
- University of Kansas Cancer Center - NorthKansas City, Egyesült ÁllamokNo longer taking part
- Aurora Cancer Care-Kenosha SouthKenosha, Egyesült ÁllamokNo longer taking part
- Illinois CancerCare-Kewanee ClinicKewanee, Egyesült ÁllamokNo longer taking part
- Gundersen Lutheran Medical CenterLa Crosse, Egyesült ÁllamokNo longer taking part
- Northwestern Medicine Lake Forest HospitalLake Forest, Egyesült ÁllamokNo longer taking part
- Sparrow HospitalLansing, Egyesült ÁllamokNo longer taking part
- OptumCare Cancer Care at CharlestonLas Vegas, Egyesült ÁllamokNo longer taking part
- OptumCare Cancer Care at Fort ApacheLas Vegas, Egyesült ÁllamokNo longer taking part
- Lawrence Memorial HospitalLawrence, Egyesült ÁllamokNo longer taking part
- Sechler Family Cancer CenterLebanon, Egyesült ÁllamokNo longer taking part
- University of Kansas Cancer Center - Lee's SummitLee's Summit, Egyesült ÁllamokNo longer taking part
- University of Kentucky/Markey Cancer CenterLexington, Egyesült ÁllamokNo longer taking part
- AMG Libertyville - OncologyLibertyville, Egyesült ÁllamokNo longer taking part
- Condell Memorial HospitalLibertyville, Egyesült ÁllamokNo longer taking part
- University of Arkansas for Medical SciencesLittle Rock, Egyesült ÁllamokNo longer taking part
- Trinity Health Saint Mary Mercy Livonia HospitalLivonia, Egyesült ÁllamokNo longer taking part
- Loma Linda University Medical CenterLoma Linda, Egyesült ÁllamokNo longer taking part
- Kaiser Permanente Los Angeles Medical CenterLos Angeles, Egyesült ÁllamokNo longer taking part
- Kaiser Permanente West Los AngelesLos Angeles, Egyesült ÁllamokNo longer taking part
- Great Lakes Cancer Management Specialists-Macomb Medical CampusMacomb, Egyesült ÁllamokNo longer taking part
- Illinois CancerCare-MacombMacomb, Egyesült ÁllamokNo longer taking part
- Solinsky Center for Cancer CareManchester, Egyesült ÁllamokNo longer taking part
- Cleveland Clinic Cancer Center MansfieldMansfield, Egyesült ÁllamokNo longer taking part
- Aurora Bay Area Medical Group-MarinetteMarinette, Egyesült ÁllamokNo longer taking part
- Carle Physician Group-Mattoon/CharlestonMattoon, Egyesült ÁllamokNo longer taking part
- Hillcrest Hospital Cancer CenterMayfield Heights, Egyesült ÁllamokNo longer taking part
- UPMC Cancer Center at UPMC McKeesportMcKeesport, Egyesült ÁllamokNo longer taking part
- UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer PavilionMechanicsburg, Egyesült ÁllamokNo longer taking part
- Baptist Memorial Hospital and Cancer Center-MemphisMemphis, Egyesült ÁllamokNo longer taking part
- Saint Luke's Cancer Institute - MeridianMeridian, Egyesült ÁllamokNo longer taking part
- Mount Sinai Medical CenterMiami Beach, Egyesült ÁllamokNo longer taking part
- Aurora Cancer Care-MilwaukeeMilwaukee, Egyesült ÁllamokNo longer taking part
- Aurora Saint Luke's Medical CenterMilwaukee, Egyesült ÁllamokNo longer taking part
- Aurora Sinai Medical CenterMilwaukee, Egyesült ÁllamokNo longer taking part
- Minneapolis VA Medical CenterMinneapolis, Egyesült ÁllamokNo longer taking part
- Community Medical HospitalMissoula, Egyesült ÁllamokNo longer taking part
- UPMC Cancer Center - MonroevilleMonroeville, Egyesült ÁllamokNo longer taking part
- UPMC Hillman Cancer Center - MonroevilleMonroeville, Egyesült ÁllamokNo longer taking part
- UPMC Hillman Cancer Center in CoraopolisMoon Township, Egyesült ÁllamokNo longer taking part
- Virtua Samson Cancer CenterMoorestown, Egyesült ÁllamokNo longer taking part
- Trinity Health Muskegon HospitalMuskegon, Egyesült ÁllamokNo longer taking part
- Arnold Palmer Cancer Center Medical Oncology NorwinN. Huntingdon, Egyesült ÁllamokNo longer taking part
- Saint Alphonsus Cancer Care Center-NampaNampa, Egyesült ÁllamokNo longer taking part
- Saint Luke's Cancer Institute - NampaNampa, Egyesült ÁllamokNo longer taking part
- UPMC Cancer Center-Natrona HeightsNatrona Heights, Egyesült ÁllamokNo longer taking part
- Baptist Memorial Hospital and Cancer Center-Union CountyNew Albany, Egyesült ÁllamokNo longer taking part
- UPMC Hillman Cancer Center - New CastleNew Castle, Egyesült ÁllamokNo longer taking part
- University of Kansas Cancer Center at North Kansas City HospitalNorth Kansas City, Egyesült ÁllamokNo longer taking part
- Cancer and Hematology Centers of Western Michigan - Norton ShoresNorton Shores, Egyesült ÁllamokNo longer taking part
- Cancer Care Center of O'FallonO'Fallon, Egyesült ÁllamokNo longer taking part
- Advocate Christ Medical CenterOak Lawn, Egyesült ÁllamokNo longer taking part
- Olathe Health Cancer CenterOlathe, Egyesült ÁllamokNo longer taking part
- Kaiser Permanente-OntarioOntario, Egyesült ÁllamokNo longer taking part
- Saint Alphonsus Medical Center-OntarioOntario, Egyesült ÁllamokNo longer taking part
- Vince Lombardi Cancer Clinic - OshkoshOshkosh, Egyesült ÁllamokNo longer taking part
- Illinois CancerCare-Ottawa ClinicOttawa, Egyesült ÁllamokNo longer taking part
- University of Kansas Cancer Center-Overland ParkOverland Park, Egyesült ÁllamokNo longer taking part
- Baptist Memorial Hospital and Cancer Center-OxfordOxford, Egyesült ÁllamokNo longer taking part
- Palo Alto Medical Foundation Health CarePalo Alto, Egyesült ÁllamokNo longer taking part
- Kaiser Permanente - Panorama CityPanorama City, Egyesült ÁllamokNo longer taking part
- Advocate Lutheran General HospitalPark Ridge, Egyesült ÁllamokNo longer taking part
- Illinois CancerCare-PekinPekin, Egyesült ÁllamokNo longer taking part
- Illinois CancerCare-PeoriaPeoria, Egyesült ÁllamokNo longer taking part
- Illinois CancerCare-PeruPeru, Egyesült ÁllamokNo longer taking part
- University of Pittsburgh Cancer Institute (UPCI)Pittsburgh, Egyesült ÁllamokNo longer taking part
- UPMC-Mercy HospitalPittsburgh, Egyesült ÁllamokNo longer taking part
- UPMC-Passavant HospitalPittsburgh, Egyesült ÁllamokNo longer taking part
- UPMC-Saint Clair Hospital Cancer CenterPittsburgh, Egyesült ÁllamokNo longer taking part
- UPMC-Saint MargaretPittsburgh, Egyesült ÁllamokNo longer taking part
- Kaiser Permanente NorthwestPortland, Egyesült ÁllamokNo longer taking part
- Kootenai Clinic Cancer Services - Post FallsPost Falls, Egyesült ÁllamokNo longer taking part
- Illinois CancerCare-PrincetonPrinceton, Egyesült ÁllamokNo longer taking part
- Aurora Cancer Care-RacineRacine, Egyesült ÁllamokNo longer taking part
- Spectrum Health Reed City HospitalReed City, Egyesült ÁllamokNo longer taking part
- Kaiser Permanente-RiversideRiverside, Egyesült ÁllamokNo longer taking part
- University of RochesterRochester, Egyesült ÁllamokNo longer taking part
- Sutter Roseville Medical CenterRoseville, Egyesült ÁllamokNo longer taking part
- Sutter Medical Center SacramentoSacramento, Egyesült ÁllamokNo longer taking part
- University of California Davis Comprehensive Cancer CenterSacramento, Egyesült ÁllamokNo longer taking part
- Marie Yeager Cancer CenterSaint Joseph, Egyesült ÁllamokNo longer taking part
- Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, Egyesült ÁllamokNo longer taking part
- Regions HospitalSaint Paul, Egyesült ÁllamokNo longer taking part
- United HospitalSaint Paul, Egyesült ÁllamokNo longer taking part
- Sainte Genevieve County Memorial HospitalSainte Genevieve, Egyesült ÁllamokNo longer taking part
- Salina Regional Health CenterSalina, Egyesült ÁllamokNo longer taking part
- Kaiser Permanente-San Diego ZionSan Diego, Egyesült ÁllamokNo longer taking part
- California Pacific Medical Center-Pacific CampusSan Francisco, Egyesült ÁllamokNo longer taking part
- Veterans Affairs Medical Center - San FranciscoSan Francisco, Egyesült ÁllamokNo longer taking part
- Kaiser Permanente-San MarcosSan Marcos, Egyesült ÁllamokNo longer taking part
- Kootenai Cancer ClinicSandpoint, Egyesült ÁllamokNo longer taking part
- Essentia Health SandstoneSandstone, Egyesült ÁllamokNo longer taking part
- North Coast Cancer CareSandusky, Egyesült ÁllamokNo longer taking part
- Prisma Health Cancer Institute - SenecaSeneca, Egyesült ÁllamokNo longer taking part
- UPMC Cancer Center at UPMC NorthwestSeneca, Egyesült ÁllamokNo longer taking part
- Vince Lombardi Cancer Clinic-SheboyganSheboygan, Egyesült ÁllamokNo longer taking part
- Sanford Cancer Center Oncology ClinicSioux Falls, Egyesült ÁllamokNo longer taking part
- Sanford USD Medical Center - Sioux FallsSioux Falls, Egyesült ÁllamokNo longer taking part
- Baptist Memorial Hospital and Cancer Center-DesotoSouthhaven, Egyesült ÁllamokNo longer taking part
- Memorial Medical CenterSpringfield, Egyesült ÁllamokNo longer taking part
- Southern Illinois University School of MedicineSpringfield, Egyesült ÁllamokNo longer taking part
- Springfield ClinicSpringfield, Egyesült ÁllamokNo longer taking part
- Missouri Baptist Medical CenterSt Louis, Egyesült ÁllamokNo longer taking part
- Saint Helena HospitalSt. Helena, Egyesült ÁllamokNo longer taking part
- Bhadresh Nayak MD PC-Sterling HeightsSterling Heights, Egyesült ÁllamokNo longer taking part
- Trinity's Tony Teramana Cancer CenterSteubenville, Egyesült ÁllamokNo longer taking part
- Cleveland Clinic Cancer Center StrongsvilleStrongsville, Egyesült ÁllamokNo longer taking part
- Missouri Baptist Sullivan HospitalSullivan, Egyesült ÁllamokNo longer taking part
- Aurora Medical Center in SummitSummit, Egyesült ÁllamokNo longer taking part
- Missouri Baptist Outpatient Center-Sunset HillsSunset Hills, Egyesült ÁllamokNo longer taking part
- Palo Alto Medical Foundation-SunnyvaleSunnyvale, Egyesült ÁllamokNo longer taking part
- ProMedica Flower HospitalSylvania, Egyesült ÁllamokNo longer taking part
- Moffitt Cancer CenterTampa, Egyesült ÁllamokNo longer taking part
- University of Kansas Health System Saint Francis CampusTopeka, Egyesült ÁllamokNo longer taking part
- Munson Medical CenterTraverse City, Egyesült ÁllamokNo longer taking part
- Upper Valley Medical CenterTroy, Egyesült ÁllamokNo longer taking part
- Saint Luke's Cancer Institute - Twin FallsTwin Falls, Egyesült ÁllamokNo longer taking part
- Vince Lombardi Cancer Clinic-Two RiversTwo Rivers, Egyesült ÁllamokNo longer taking part
- UPMC Cancer Center-UniontownUniontown, Egyesült ÁllamokNo longer taking part
- UPMC Uniontown Hospital Radiation OncologyUniontown, Egyesült ÁllamokNo longer taking part
- Carle Cancer CenterUrbana, Egyesült ÁllamokNo longer taking part
- Sutter Solano Medical Center/Cancer CenterVallejo, Egyesült ÁllamokNo longer taking part
- Essentia Health Virginia ClinicVirginia, Egyesült ÁllamokNo longer taking part
- Virtua VoorheesVoorhees Township, Egyesült ÁllamokNo longer taking part
- Great Lakes Cancer Management Specialists-Macomb Professional BuildingWarren, Egyesült ÁllamokNo longer taking part
- Saint John Macomb-Oakland HospitalWarren, Egyesült ÁllamokNo longer taking part
- South Pointe HospitalWarrensville Heights, Egyesült ÁllamokNo longer taking part
- Northwestern Medicine Cancer Center WarrenvilleWarrenville, Egyesült ÁllamokNo longer taking part
- UPMC Washington Hospital Radiation OncologyWashington, Egyesült ÁllamokNo longer taking part
- Aurora Cancer Care-Milwaukee WestWauwatosa, Egyesült ÁllamokNo longer taking part
- AdventHealth Infusion Center WeavervilleWeaverville, Egyesült ÁllamokNo longer taking part
- Aurora West Allis Medical CenterWest Allis, Egyesült ÁllamokNo longer taking part
- UPMC West Mifflin-Cancer Center JeffersonWest Mifflin, Egyesült ÁllamokNo longer taking part
- University of Kansas Hospital-Westwood Cancer CenterWestwood, Egyesült ÁllamokNo longer taking part
- Presbyterian Intercommunity HospitalWhittier, Egyesült ÁllamokNo longer taking part
- Kaiser Permanente-Woodland HillsWoodland Hills, Egyesült ÁllamokNo longer taking part
- Cleveland Clinic Wooster Family Health and Surgery CenterWooster, Egyesült ÁllamokNo longer taking part
- Metro Health HospitalWyoming, Egyesült ÁllamokNo longer taking part
- UPMC MemorialYork, Egyesült ÁllamokNo longer taking part
- WellSpan Health-York Cancer CenterYork, Egyesült ÁllamokNo longer taking part
- WellSpan Health-York HospitalYork, Egyesült ÁllamokNo longer taking part
- Huron Gastroenterology PCYpsilanti, Egyesült ÁllamokNo longer taking part
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor CampusYpsilanti, Egyesült ÁllamokNo longer taking part
Trial details
- Who runs it
- SWOG Cancer Research Network
- Trial code
- NCT05364645
- Record updated
- 2024. július 9.
- Original description
This phase II Lung-MAP treatment trial tests whether carboplatin and pemetrexed with or without selpercatinib works to shrink tumors in patients with RET fusion-positive non-small cell lung cancer that is stage IV or has not responded to previous RET directed therapy. Chemotherapy drugs, such as carboplatin and pemetrexed, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Selpercatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving selpercatinib in combination with carboplatin and pemetrexed may help lower the chance of the cancer growing and spreading.Read full original descriptionShow less
A Randomized Phase II Study of Carboplatin and Pemetrexed w/ or w/o Selpercatinib in Participants With Non-Squamous RET Fusion-Positive Stage IV Non-Small Cell Lung Cancer and Progression of Disease on Prior RET Directed Therapy (Lung-MAP Sub-Study)
This phase II Lung-MAP treatment trial tests whether carboplatin and pemetrexed with or without selpercatinib works to shrink tumors in patients with RET fusion-positive non-small cell lung cancer that is stage IV or has not responded to previous RET directed therapy. Chemotherapy drugs, such as carboplatin and pemetrexed, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Selpercatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving selpercatinib in combination with carboplatin and pemetrexed may help lower the chance of the cancer growing and spreading.
Inclusion: Participants must have stage IV or recurrent disease; Participants must have been assigned to S1900F based on biomarker analysis of tissue and/or blood and determined to have RET fusion-positive NSCLC as defined here:; Participants must have RET fusion-positive NSCLC as determined by the Foundation Medicine (FMI) tissue-assay or other tumor-based assays such as next generation sequencing (NGS), polymerase chain reaction (PCR), or fluorescent in situ hybridization (FISH), or by cfDNA blood assay as outlined in the LUNGMAP Screening Protocol. Participants previously tested for and determined to have RET-fusion-positive NSCLC outside of LUNGMAP, must also submit tissue for central FMI testing on the LUNGMAP Screening Protocol. Participants with RET fusions detected by IHC alone are not eligible. The testing must be done within a laboratory with Clinical Laboratory Improvement Act (CLIA), International Organization for Standardization (ISO)/International Electrotechnical Commission (IEC), College of American Pathologists (CAP), or similar certification. Presence of RET fusions detected on tests performed outside of LUNGMAP must have been confirmed by the study biomarker review panel; Participants must be negative for all additional validated oncogenic drivers that could cause resistance to selpercatinib treatment. This includes EGFR sensitizing mutations, EGFR T790M mutations, ALK gene fusions, ROS1 gene fusion, KRAS activating mutations, BRAF V600E mutation and MET exon 14 skipping mutations or high-level amplification and expression; NOTE: EGFR, ALK, ROS, KRAS, and BRAF testing is performed as part of the LUNGMAP screening/pre-screening FoundationOne test. If prior data is not available, results from the FMI testing must be obtained prior to sub-study randomization; Participants must have measurable disease documented by computed tomography (CT) or magnetic resonance imaging (MRI). The CT from a combined positron emission tomography (PET)/CT may be used to document only non-measurable disease unless it is of diagnostic quality. Measurable disease must be assessed within 28 days prior to sub-study randomization. Pleural effusions, ascites and laboratory parameters are not acceptable as the only evidence of disease. Non-measurable disease must be assessed within 42 days prior to sub-study randomization. All disease must be assessed and documented on the Baseline Tumor Assessment Form. Participants whose only measurable disease is within a previous radiation therapy port must demonstrate clearly progressive disease (in the opinion of the treating investigator) prior to randomization; Participants must have a CT or MRI scan of the brain to evaluate for central nervous system (CNS) disease within 42 days prior to sub-study randomization; Participants must have received and developed disease progression during or after an anti-RET inhibitors treatment. The anti-RET inhibitor therapy must be the most recent therapy; Participants must have progressed (in the opinion of the treating physician) following the most recent line of therapy; Participants must have recovered (=< grade 1) from any side effects of prior therapy. Participants must not have received any radiation therapy within 14 days prior to sub-study randomization; For participants with stage IV or recurrent disease, the participant must not have received a platinum-based chemotherapy regimen. For participants whose prior systemic therapy was for stage I-III disease only (i.e., participant has not received any treatment for stage IV or recurrent disease), disease progression on platinum-based chemotherapy must not have occurred within one year (365 days) from the last date that the participant received that therapy. Prior anti-PD-1/PD-L1 therapy, alone or in combination (e.g., nivolumab, pembrolizumab, or durvalumab) is allowed; Participants must have an electrocardiogram (ECG) performed within 28 days prior to sub-study randomization. It is suggested that a local cardiologist review the corrected QT by Fridericia's correction formula (QTcF) intervals; Absolute neutrophil count (ANC) >= 1.5 x 10\^3/uL obtained within 28 days prior to sub-study randomization; Platelet count >= 100 x 10\^3/uL obtained within 28 days prior to sub-study randomization; Hemoglobin >= 9 g/dL obtained within 28 days prior to sub-study randomization; Serum bilirubin =< institutional upper limit of normal (IULN) and either alanine aminotransferase (ALT) or aspartate aminotransferase (AST) =< 2 x IULN within 28 days prior to sub-study randomization (if both ALT and AST are done, both must be < 2 x IULN). For participants with liver metastases, bilirubin and either ALT or AST must be =< 5 x IULN (if both ALT and AST are done, both must be =< 5 x IULN); Participants must have a serum creatinine =< the IULN OR measured or calculated creatinine clearance >= 50 mL/min using the following Cockcroft-Gault Formula. This specimen must have been drawn and processed within 28 days prior to sub-study randomization; Participants must have Zubrod performance status 0-1 documented within 28 days prior to sub-study randomization; Participants must provide pre-study history and physical exam within 28 days prior to sub-study randomization; Participants with evidence of chronic hepatitis B virus (HBV) infection must have undetectable HBV viral load on suppressive therapy within 28 days prior to sub-study randomization; Participants with a history of hepatitis C virus (HCV) infection must have been treated and cured. Participants with HCV infection who are currently on treatment must have an undetectable HCV viral load within 28 days prior to sub-study randomization; Participants with known human immunodeficiency virus (HIV) infection are eligible, provided they are on effective anti-retroviral therapy and have undetectable viral load at their most recent viral load test and within 6 months prior to sub-study randomization; Participants must be able to swallow capsules; Participants must agree to have blood specimens submitted for circulating tumor DNA (ctDNA); Participants must also be offered participation in banking and in the correlative studies for collection and future use of specimens; Participants with impaired decision-making capacity are eligible as long as their neurological or psychological condition does not preclude their safe participation in the study (e.g., tracking pill consumption and reporting adverse events to the investigator); Participants must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines.
Exclusion: Participants must not have leptomeningeal disease, spinal cord compression or brain metastases unless: (1) metastases have been locally treated and have remained clinically controlled and asymptomatic for at least 14 days following treatment, and prior to sub-study randomization, AND (2) participant has no residual neurological dysfunction and has been off corticosteroids for at least 24 hours prior to sub-study randomization; Participants must not have received any prior systemic therapy (systemic chemotherapy, tyrosine kinase inhibitor [TKI], immunotherapy or investigational drug) within 14 days prior to sub-study randomization; Participants must not be planning to receive any concurrent chemotherapy, immunotherapy, biologic or hormonal therapy for cancer treatment while receiving treatment on this study. Concurrent use of hormones for non-cancer-related conditions (e.g., insulin for diabetes and hormone replacement therapy) is acceptable; Participants must not have a prior or concurrent malignancy whose natural history or treatment (in the opinion of the treating physician) has the potential to interfere with the safety or efficacy assessment of the investigational regimen; Participants must not have had a major surgery within 14 days prior to sub-study randomization. Participants must have fully recovered from the effects of prior surgery in the opinion of the treating investigator; Participants must not be pregnant or nursing. Individuals who are of reproductive potential must have agreed to use an effective contraceptive method with details provided as a part of the consent process. A person who has had menses at any time in the preceding 12 consecutive months or who has semen likely to contain sperm is considered to be of "reproductive potential." In addition to routine contraceptive methods, "effective contraception" also includes refraining from sexual activity that might result in pregnancy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) including hysterectomy, bilateral oophorectomy, bilateral tubal ligation/occlusion, and vasectomy with testing showing no sperm in the semen; Participants must not have any grade III/IV cardiac disease as defined by the New York Heart Association Criteria (i.e., participants with cardiac disease resulting in marked limitation of physical activity or resulting in inability to carry on any physical activity without discomfort), unstable angina pectoris, and myocardial infarction within 6 months, or serious uncontrolled cardiac arrhythmia.