One-month Latent Tuberculosis Treatment for Renal Transplant Candidates

Korábbi kezelés

• Prior history of treatment for active TB or LTBI
• Active drug or alcohol dependence in opinion of investigator that will interfere with adherence
• On non-modifiable medications with significant drug interactions with Rifapentine or INH
• On medications known to cause hepatoxicity and/or neutropenia

Más betegség

• Known history of or active porphyria
• History of liver cirrhosis
• Evidence of active acute hepatitis

Laborértékek

• Absolute neutrophil count of <750 cells/mm3
• Hemoglobin < 7.4 g/dL
• Platelets < 50 x 10E3/uL
• AST (SGOT) and ALT (SGPT) > 3 times the upper limit of normal (ULN)
• Total bilirubin > 2.5 times the ULN

Életkor

• Age <18 years

Egyéb

• Presence of active TB
• Known exposure to multidrug-resistant TB
• Peripheral neuropathy > grade 2

• Men and Women Age > 18
• Weight > 30 kg
• End-stage renal disease
• Living-related or deceased kidney transplant candidate (not on the waitlist) deemed by their transplant nephrologist
• Negative serum OR urine pregnancy test
• Evidence of latent tuberculosis or high risk for tuberculosis: (1) Confirmed positive tuberculin skin test (TST) ≥ 5 mm or positive quantiferon gold test/T-spot and a chest radiograph or chest CT scan without evidence of active pulmonary TB OR (2) Patients with negative TST or quantiferon gold/T-spot test but high risk for tuberculosis are eligible if they have (i) radiographic evidence of previous TB (stable fibronodular changes, including scarring [peribronchial fibrosis, bronchiectasis, and architectural distortion] and nodular opacities in the apical and upper lung zones) and no history of adequate treatment, or (ii) have had close and prolonged contact with a case of active TB.