Effectiveness of Cannabinoids on Appetite in Scleroderma

Korábbi kezelés

• Previous allergy to cannabinoid or their derivatives
• Concomitant illegal drug used (amphetamine or its derivative, cocaine)
• History of the previous cannabinoid using or concomitant any herbal included cannabinoid used
• Having a history of schizophrenia, concurrent active mood disorder, or anxiety disorders
• Receiving the following medications that cause drug interaction with cannabinoids: fluoroquinolone, rifampicin, fluoxetine, warfarin

Más betegség

• Overlap with other connective tissue diseases
• Evidence of active malignant disease
• Present active infection that needs systemic antibiotic
• Having active SSc that needs closed monitoring for disease progression (pulmonary hypertension, proteinuria, microscopic hematuria, digital gangrene, and progressive interstitial lung disease)
• Having unstable cardiopulmonary disease (angina, peripheral vascular disease, cerebrovascular disease, and arrhythmia) and risk of cardiovascular disease

Laborértékek

• Present uncontrolled or severe medical problems including diabetes mellitus, asthma, angina, cardiovascular, thyroid, hepatic, or renal diseases (Cr>1.4 mg/dl)

Egyéb

• Pregnancy or lactation
• Bedridden and confined to no self-care
• On-going anxiolytics, hypnotics, or sleeping pills used
• In a period that needs immunosuppressant dose adjustment

• SSc patients aged between 18 and 70 years
• Diagnosed according to ACR/EULAR 2013 classification criteria
• Having anorexia or malnutrition status
• Must not receive steroid equivalent to prednisolone dose more than 10 mg/d
• Must receive a stable dose of steroid, immunosuppressant, and/or vitamin or its supplement within 2 weeks before enrollment
• Must stop anxiolytics, hypnotics, or sleeping pills at least 2 weeks before enrollment
• Understand and able to read and write the Thai language