CoQ10 and Exercise for Mitochondrial Dysfunction in Advance Kidney Disease

Korábbi kezelés

• History of functional transplant less than 6 months prior to study
• Use of immunosuppressive drugs within 1 month prior to study
• Acute infectious disease within 1 month prior to study
• Anticipated live donor kidney transplant

Más betegség

• Active connective tissue disease
• AIDS (HIV seropositivity is not an exclusion criterion)
• Acute myocardial infarction or cerebrovascular event within 3 months
• Prolonged ongoing (greater than 20 minutes) angina at rest
• Angina at rest with transient ST changes greater than 0.05 mV on ECG
• Elevated cardiac enzymes (e.g., troponin Tor I greater than 0.1mg/ml)
• Advanced liver disease, with a modified Child-Turcotte-Pugh score equal or greater than 10.
• Active malignancy excluding basal cell carcinoma of the skin
• History of poor adherence to hemodialysis or medical regimen
• Subjects with cardiac pacemaker, artificial heart valve, any metallic implant, permanent tattoo, or any retained foreign metallic bodies.
• Contraindication for exercise such as electrolyte abnormalities, uncontrolled arrhythmias, or pulmonary congestion.

Laborértékek

• Ejection fraction less than 30%
• Pre-dialysis potassium repeatedly higher than 5.5 mmol/L (confirmed on a repeated blood draw)

Egyéb

• Body mass index > 35 mg/kg2
• Uncontrolled blood pressure
• New or worsening mitral regurgitation murmur
• Hypotension, bradycardia, or tachycardia
• Sustained ventricular tachycardia on ECG
• Gastrointestinal dysfunction requiring parental nutrition
• Inability to provide consent
• Inability to perform exercise

• Subjects age 18 to 75 years
• On thrice-weekly chronic hemodialysis for at least 6 months (only applicable for patients with ESRD on maintenance hemodialysis).
• Clinically stable, adequately dialyzed (single-pool Kt/V >1.2) thrice weekly, for at least 3 consecutive months prior to the study (only applicable for patients with ESRD on maintenance hemodialysis)