Safety and Feasibility of Dasatinib and Quercetin in Adults at Risk for Alzheimer's Disease

Korábbi kezelés

• Unwilling to take study medications or follow study protocol
• Drug or alcohol abuse in the last 5 years,

Más betegség

• Allergies to Dasatinib or Quercetin,
• Unstable coronary artery disease (myocardial infarction within 6 months or angina),
• Stroke or transient ischemic attack in the past 6 months,
• Chronic heart failure,
• Current or chronic history of liver disease,
• Neurodegenerative disease including Parkinson's disease,
• Chronic renal disease,
• History or current diagnosis of pulmonary hypertension,

Laborértékek

• QTc prolongation,
• Prolonged prothrombin time or INR,
• Chronic use of any of the following medications: anti-arrhythmic medications, antipsychotics, anxiolytics, anti-platelet or anti-coagulant medications other than aspirin, quinolone antibiotics, or drugs metabolized by the same liver enzymes as Quercetin or Dasatinib.

Egyéb

• Telephone MoCA score \<10 points
• Inability to independently perform Katz Activities of Daily Living (ADLs),
• Hospitalization within 6 months,
• Anemia,
• Thrombocytopenia,
• Neutropenia,
• Indications of current fluid retention,
• Inability to insonate the middle cerebral artery through a temporal bone window on at least one side using transcranial Doppler ultrasound, or

• Men and women \>/= 65 years
• Ambulatory,
• Community dwelling,
• Slow gait speed (\<1 m/second),
• Mild Cognitive Impairment (Telephone MoCA score \<21, which is indicative of cognitive impairment)