Effect and Long-Term Outcomes of Indocyanine Green Fluorescence Imaging Method Versus Modified Inflation-Deflation Method in Identification of Intersegmental Plane（IMPLANE-0529）

Korábbi kezelés

• Patient who had received antitumor therapy (radiotherapy, chemotherapy, targeted therapy, immunotherapy) prior to surgery;
• Prior history of unilateral thoracotomy;

Más betegség

• Patient with a history of iodine or indocyanine green allergy;
• Patient with a history of other malignancies;
• Patient with secondary primary cancer at enrollment;
• Small cell lung cancer;
• An active bacterial or fungal infection that is difficult to control;
• Severe mental illness;
• History of severe heart disease , heart failure , myocardial infarction or angina pectoris within the last 6 months;

Egyéb

• Woman in pregnant or breastfeeding period;
• Patient with interstitial pneumonia, pulmonary fibrosis or severe emphysema;
• patient that researcher considers inappropriate to participate in this study.

• Aged 18 to 80 years old;
• According to the surgical standards of the Eighth edition of People's Medical Publishing House, patients whose blood pressure was under 160/100mmHg and blood glucose was under 5.6-11.2mmol /L with normal functions of major organs such as heart, lung, liver and kidney before surgery are included. The main criteria are as follows:
  • Cardiac function examination indicated Goldman index grade 1-2; ii. Pulmonary function examination suggested postoperative predicted FEV1≥40% and DLCO≥40%; iii. Total bilirubin ≤1.5 times the upper limit of normal; iv. Alanine aminotransferase and aspartate aminotransferase ≤2.5 times the upper limit of normal value; v. Creatinine ≤1.25 times the upper limit of normal value and creatinine clearance ≥60ml/min;
• The center of the lesion is located in the other lobes except the middle lobe, and in the middle and outer third of the lung;
• The maximum diameter of the tumor was not more than 2cm on TLC(Thin layer CT) scan and the clinical stage was cT1a-1bN0M0(according to AJCC staging criteria, eighth edition);
• Consolidation tumor rate <1；
• ECOG PSscore 0-1;
• All relevant examinations should be completed within 28 days before surgery;
• Patients who understand the study and have signed informed consent.