NCT05463666Fut, nem toboroz
STudying Ageing in Rheumatic Diseases (STAR)
Effect of Ageing on Interpretation of Disease Activity Measures and on Cognition, Physical Activity and Performance in Patients With Rheumatic Disorders
Forrás: ClinicalTrials.gov · Utoljára frissítve: 2025. okt. 1.
Rövid összefoglaló (regiszter, angolul)
The primary objective of the STAR study is to investigate how measures of disease activity and measures for cognition, physical activity and performance behave in ageing population controls and patients with rheumatoid arthritis (RA). If an differential effect of age on outcome over time is apparent, the presence of an inclination point will be assessed. The secondary objective is to investigate additional factors (e.g. lifestyle factors) that might explain any differences between ageing controls and RA patients. The STAR study is an observational cross-sectional matched case-control study including 420 RA patients and 420 population controls between 55-85 years of age, stratified by five year intervals. All participants will complete generic and RA-specific questionnaires. A subset of 180 participants will be visiting the research center for physical examination and performance tests. Expected outcomes include practical age-specific reference curves that will be constructed for a selection of outcomes (e.g. DAS28). It is expected that as RA is characterized by tender and painful joints, e.g. the number of tender joints has a higher starting point in RA patients than in the general population. This will most likely increase in both groups with age, although the general population may catch up at an older age. Measures of cognitive status may show a steeper decline with age in RA patients compared to the general population. Measures of physical activity and performance will presumably have a worse starting point in RA patients than in the general population, and might show a steep decline with age. The general population might however catch up with the patients with RA. Most probably, age will not be the only factor explaining 'worse' outcomes in both RA patients and the general population. Other factors such as lifestyle factors (e.g. smoking, diet, BMI, occupation) and comorbidities will probably play a role.
- Állapot (regiszter)
- Fut, nem toboroz
- Vizsgálattípus
- Megfigyeléses
- Résztvevők száma
- 840 (tervezett)
- Első benyújtás
- 2022. júl. 1.
- Kezdés
- 2022. dec. 1.
- Elsődleges befejezés
- 2025. ápr. 22.
- Fő szponzor
- Maastricht University Medical Center
- Betegségek
- Rheumatoid arthritis
- NCT-szám
- NCT05463666
Mit vállalsz
- Vizsgálat típusa: Megfigyeléses
- Tervezett résztvevők: 840
- 2022. dec. 1. és az elsődleges befejezés (2025. ápr. 22.) között
- 1 helyszín, 1 országban
- Vizitek és vizsgálatok: kérdezd a vizsgálat csapatát, a regiszter nem sorolja fel őket
A(z) ClinicalTrials.gov regisztermezőiből összeállítva. A vizsgálat felépítését írja le.
Ki nem vehet részt
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Más betegség
- A diagnosis of dementia or mental incompetency is always reason for exclusion.
Egyéb
- Subject is the spouse/partner of the included RA patient.
- Have severe comorbidity and the treating rheumatologist and/or research team decides they should not be included in the study because of health reasons.
- Persons of whom the research team estimates that his/her life expectancy is less than 2 years.
- Do not understand the Dutch language and/or are notable to understand the study information.
Kiket keres a vizsgálat
- Age between 55-85 years at baseline.
- Diagnosis of RA by treating rheumatologist.
- Age between 55-85 years at baseline.
- No diagnosis of RA, or other inflammatory RMD (osteoarthritis allowed).
Életkor a regiszterben: 55 év – 85 év · Nem: nők és férfiak
Helyszínek (1)
Helyszínek a regiszter sorrendjében. Ha a profilodba mented a városodat, távolság szerint rendeződnek.
| Helyszín | Város | Ország | Helyszín állapota |
|---|---|---|---|
| Maastricht UMC | Maastricht | Hollandia | Ismeretlen állapot |
Ez az oldal tájékoztatás, nem orvosi tanács. Bármely vizsgálatról az orvosoddal beszélj.