Evaluation of Metformin Effect on the Fertility of Women Treated With 131I for Thyroid Cancer

Más betegség

• Hypersensitivity to metformin.
• Subjects with polycystic ovarian syndrome or other diseases of the ovaries (primary / secondary ovarian failure).
• Subjects with lactic acidosis or having history of metabolic acidosis.
• Subjects with history of congestive heart disease NYHA stage III/IV.
• Subjects with acute myocardial ischemia (CCS 3-4).
• Subjects with history of sepsis or severe infection.
• Subject with lung disease (uncontrolled asthma based on GINA 2000 Guidelines and COPD GOLD ≥ 3 stage).
• Alcohol or other substance dependent syndromes.
• Accompanying diseases with poor prognosis in the opinion of the researcher.
• As per Investigator (or his designee) judgement, subject cannot participate in the study due to reasons (i.e. medical, psychiatric and/or social reason).

Laborértékek

• Subjects with liver malfunction and abnormal hepatitis marker results (ALT and AST activity \>3ULN.\*
• Subjects with eGFR below 45ml/min/1.73m2.\*
• Subjects with serum AMH concentration\* below lower range norm.
• Unreliability or lack of cooperation. \*based on the laboratory results from screening visit

Egyéb

• Subjects taking metformin during last week.
• Positive result of pregnancy test or pregnancy planned during the study.
• BMI \<18.5 kg/m2.

• Female subjects in reproductive age \>18 \<45 years.
• Subjects with diagnosed papillary thyroid carcinoma with various pathological stage TNM (I-II).
• Subjects not treated with 131I
• Willingness to comply with protocol procedures.