Dietary Supplement on the Intestinal Microbiota in Patients with Colon Cancer

Korábbi kezelés

• Previous gastrointestinal resections, except for appendectomy or surgery required to treat colon neoplasia
• Chronic and continued use of NSAIDs or corticosteroids
• Previous or concomitant neoplasia, unless curative treatment was received and ≥5 years have passed free of disease

Más betegség

• Systemic autoimmune diseases (systemic lupus erythematosus, antiphospholipid syndrome, Sjögren's syndrome, progressive systemic sclerosis -scleroderma-, idiopathic inflammatory myopathies -myositis-, vasculitis, Behçet's disease, relapsing polychondritis, etc.)
• Mellitus diabetes type 1
• Chronic intestinal pathologies (inflammatory bowel disease, celiac disease, lymphangiectasias)
• Allergy to any component of the product under investigation
• History of familial adenomatous polyposis mediated by the APC gene or by Lynch syndrome (mutations MLH1, MSH2, PMS2, MSH6).

Egyéb

• Continued consumption of probiotics, with the exception of dairy products or other natural fermented foods
• Pregnancy
• Mean consumption of > 3 UBE of alcohol per day
• ECOG scale greater than or equal to 3 at the start of the clinical trial
• Grade 3-4 neuropathy that limits the use of oxaliplatin.
• Patients with partial or complete deficiency of the enzyme dihydropyrimidine dehydrogenase (DPD), which causes poor metabolism and the use of fluoropyrimidines is contraindicated.

• Diagnosis of stage II or III colo neoplasia
• Indication of adjuvant chemotherapy according to the Protocols for the diagnosis and treatment of cancer of the Intercenter Clinical Management Unit
• Sign the informed consent