MIBG in Aging and Neurologic Disorders

Más betegség

• Active medical disorder that could preclude participation in this protocol
  • Hypersensitivity to the radioligand or iodine
  • Myocardial infarction or cerebral infarct over preceding year, stable or unstable angina, known symptomatic coronary artery disease
  • Renal disease viewed by the physician to be too severe to warrant myocardial 123I-MIBG scintigraphy imaging
  • History of significant alcohol or drug abuse
  • Any other medical disorder considered by the study physicians as inappropriate for enrollment in this protocol
• Caregiver is not with a patient with dementia or severe parkinsonism at least 4 hours/day for at least 5 days/week

Egyéb

• Does not fulfill criteria for any of the desired diagnoses
• Women with intact uterus and not post-menopausal unless pregnancy test performed at screening is negative
• Women who are pregnant or are breast-feeding an infant
• STMS score <10
• Patient or caregiver unwilling or unable to participate in all study-related procedures
• Patient or caregiver unwilling or unable to provide informed consent

• Diagnosis of one of the syndromes/diagnoses of interest using established criteria
• STMS score above 10
• No active medical disorder that could preclude participation
• Stable medication regimen over previous four weeks
• Absence of certain medications that could significantly impact the myocardial 123I-MIBG scintigraphy findings
• For those with dementia, caregiver that is with the patient at least 4 hours/day for at least 5 days per week
• For those with dementia, or severe parkinsonism, patient and caregiver willing and able to participate in all study-related procedures
• Patient is capable of giving informed consent, or if appropriate, has caregiver capable of giving consent on the subject's behalf.