Cognitive Markers in Prodromal MS

Korábbi kezelés

• Have any irremovable piercings, metallic based-tattoos, or MRI-contraindicated implants (e.g. pacemakers and defibrillators)

Más betegség

• Primary psychiatric disorder that would influence ability to participate.
• Current uncontrolled seizure disorder.
• Current substance abuse disorder.
• History of head trauma in the past year (e.g., head injury, brain surgery) or medical device implanted in the head (such as Deep Brain Stimulator) or in the neck (such as a Vagus Nerve Stimulator).
• Any skin disorder/sensitive skin (e.g., eczema, severe rashes), blisters, open wounds, burn including sunburns, cuts or irritation, or other skin defects which compromise the integrity of the skin at or near stimulation locations (where electrodes are placed)
• Treatment for a communicable skin disorder currently or over the past 12 months

Életkor

• Presence of severe cognitive impairment (based on SDMT age normative z-score <-3.0).

Egyéb

• Below average estimated premorbid cognitive functioning (based on WRAT-4 reading recognition standard z-score < 85).
• Pregnant or breastfeeding
  • Additional Exclusion Criteria for tDCS-MRI Participants
• Extreme claustrophobia

• Ages 23-59 years old (inclusive)
• Prodromal MS (defined by radiologically isolated syndrome ≤ 6 months from first MRI or clinically isolated syndrome ≤ 3 months from first clinical event)