A Study of Tirzepatide (LY3298176) in Adult Participants With Type 2 Diabetes Switching From Dulaglutide (SURPASS-SWITCH)

Korábbi kezelés

• Have any of these cardiovascular (CV) conditions within 60 days prior to screening:
  • acute myocardial infarction,
  • cerebrovascular accident (stroke), or
  • hospitalization due to congestive heart failure (CHF).
• Have within 90 days prior to screening received treatment with medications intended to promote weight loss. This includes prescribed, over-the-counter, or alternative remedies
• Have been treated with insulin prior to screening
  • Exception: use of insulin for gestational diabetes or short-term use (<14 days) for acute conditions such as acute illness, hospitalization, or elective surgery.

Más betegség

• Have type 1 diabetes
• Have a history of chronic or acute pancreatitis
• Have a history of
  • proliferative diabetic retinopathy, or
  • diabetic maculopathy, or
  • nonproliferative diabetic retinopathy that requires acute treatment.
• Have New York Heart Assocation (NYHA) Functional Classification Class IV CHF
• Have family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN2).
• Have a history of reduction of dose of dulaglutide, due to intolerability, without successful reescalation

Laborértékek

• Have an estimated glomerular filtration rate (eGFR) <30 mL/minute/1.73 m2 (or lower than the country-specific threshold for discontinuing metformin therapy per local label)

• Have type 2 diabetes
• Have HbA1c ≥7.0% (≥53 mmol/mol) to ≤9.5% (≤80 mmol/mol)
• Are currently on a stable dose of dulaglutide weekly (0.75 mg or 1.5 mg) for at least 6 months prior to screening.
• No treatment with oral antihyperglycemic medication (OAM), or on a stable dose of up to 3 OAMs, which may include metformin, sodium glucose cotransporter-2 inhibitors (SGLT-2i), and/or sulfonylurea, for at least 3 months before screening.
• Have had stable body weight (±5%) during the 90 days preceding screening
• Have BMI ≥25 kilogram/square meter (kg/m²)