Anti-Platelets in Chronic Obstructive Pulmonary Disease

Korábbi kezelés

• Regular use of aspirin, clopidogrel or another antiplatelet medication;
• Daily use of oral steroids, theophylline, roflumilast, or loop diuretics;
• Use of a biologic medication with regular injections;
• IV drug use within the last year;
• Exacerbation of respiratory symptoms within the previous 6 weeks, such as that requiring hospitalization, oral prednisone or antibiotics to control symptoms, or longer and not yet returned to baseline; and

Más betegség

• Allergy to aspirin, clopidogrel, albuterol or iodine/IV contrast;
• History of intracranial hemorrhage, severe GI bleed or other life-threatening bleed;
• History of organ transplant or autoimmune disease on systemic therapy (rheumatoid arthritis, lupus);
• Other current lung disease (interstitial lung disease, idiopathic pulmonary fibrosis, asthma);
• History of lung surgery to remove part of the lung;
• Treatment for cancer (systemic therapy or surgical/radiation within the thorax) in the last 12 months;
• Known diagnosis of pulmonary hypertension;
• Known systolic heart failure (RV or LV EF < 40%);
• Chest, abdominal or eye surgery, or a heart attack or stroke, within the last 3 months.

Laborértékek

• Platelet count < 150,000/dL or self-report of a bleeding disorder;
• Acute or chronic renal insufficiency (estimated glomerular filtration rate [GFR] <60 mL/min/1.73 m2 or self-report). GFR will be calculated using the CKD-EPI equation;

Egyéb

• BMI > 35;
• Use of blood thinner (e.g. warfarin, lovenox or novel oral anti-coagulants);
• Continuous use of supplemental oxygen at home;
• Regular use of an NSAID;
• Known bullae or advanced destructive emphysema in more than 1/3 of the lungs;
• Current or planned pregnancy in the next year;
• Regular marijuana smoking;

• COPD (FEV1/FVC < 0.7, FVC >= LLN), GOLD Stage I/II/III (FEV1 >= 40%)
• Current or former smoker of at least 10 pack years
• Normal lung function (FEV1/FVC >= 0.7, FEV1 and FVC >= LLN)
• Current or former smoker of at least 10 pack years