Immune Response of Shingrix Vaccine in People Living With HIV (> 50 y.o.) Compared to Age-matched Controls

Korábbi kezelés

• Intake of drugs which suppress the immune system (e.g. glucocorticoids for a long time \[an equivalent dose of prednisolone \>20 mg/day \> 3 months\], monoclonal antibodies, cytostatics, biological products, etc.) within 6 months before screening.
• Administration of immunoglobulins or any blood products within 3 months preceding the first dose of vaccine or planned administration during the study period
• Having received a vaccine in the last month or is expected to receive a vaccine in the next month
• Having received a shingles vaccine within one year
• Presented with herpes zoster in the previous year
• Participation in another study with investigational drug within the 30 days preceding and during the present study.

Más betegség

• Ongoing signs of febrile or non-febrile infection at the time of the first vaccination
• Unable to provide informed consent or inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant

Életkor

• Immunosuppression from the following:
  • Current malignant neoplasm;
  • primary immunodeficiency;
  • recent (\<2 years) solid or bone-marrow transplant or any transplant still requiring immunosuppressive therapy
• (France) Patient governed by articles L 1121-5 to L 1121-8 (persons deprived of their liberty by a judicial or administrative decision, minors, persons of legal age who are the object of a legal protection measure or unable to express their consent)

Egyéb

• Contra-indication to RZV
• Hospitalized patients
• (France) Pregnant or breastfeeding woman

• For PLWH:
• Be registered in the SHCS or in the ANRS CO3 Aquitaine Cohort
• Age \>50 YOA
• Time since cART initiation \> 10 years
• Not already vaccinated with RZV
• HIV viral load \<50 copies/ml (within 6 months from the last blood sampling)
• Informed consent as documented by signature
• (France) : Person affiliated with or beneficiary of the French social security scheme
  • For aged/gender-matched controls
• Age \>50 YOA
• Not already vaccinated with RZV
• Informed consent as documented by signature
• (France) Not HIV infected
• (France) Person affiliated with or beneficiary of the French social security scheme