Innate Immunity Stimulation Via TLR9 in Early AD

Korábbi kezelés

• Use of corticosteroids or immunosuppressive drugs within 30 days of study entry
• Current use of drugs that are major substrates of cytochrome P450 (CYP) enzyme 1A2

Más betegség

• History of psychiatric illness (e.g. hallucinations, major depression, suicidal ideation or delusions) that could interfere with completion of study related procedures as determined by PI
• History of autoimmune disorders or antibody-mediated disease, severe asthma, or other serious infection or systemic illness, as determined by PI
• History of splenectomy
• Renal impairment
• History of TIA, stroke or seizures within 12 months of screening
• Any neurological condition other than AD that could contribute to cognitive impairment (including related to possible "long COVID") as determined by PI
• Recent exposure to COVID-19 infection within 14 days or recent onset of symptoms within 14 days that may be related to COVID-19 infection

Egyéb

• Use of chloroquine within 8 weeks of study entry
• Inability to undergo MRI imaging
• Participation in any other current AD investigational interventional trial
• Current use of an anti-coagulant

• 65-85 years of age
• MCI due to AD or mild AD dementia per NIA-AA specified criteria published in 2018
• Montreal Cognitive Assessment (MoCA) score ≥17 AND;
• Positive Florbetaben PET amyloid scan, or other positive PET amyloid scan performed within one year of study enrollment
• Must be able to provide consent or assent (If applicable).
• Must be willing and able to participate in all study related procedures.
• Must have a reliable study partner to provide information on the subject's cognitive and functional status. Study partner must have sufficient contact with the subject, as determined by the PI, and be available to accompany the subject to clinic visits or by phone.