Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression

Korábbi kezelés

• Lithium Therapy
• Previous participation in this study; a patient may not re-enroll in another study while in this study

Más betegség

• History of Bipolar Disorder, Obsessive Compulsive Disorder, antisocial personality disorder, borderline personality disorder, and congestive cardiac failure
• Uncontrolled hypertension (BP >140 mm Hg systolic and/or >90 mm Hg diastolic on two separate readings at the time of screening) or on 2 medications for hypertension
• History of Gastrointestinal hemorrhage, renal and hepatic insufficiency
• Allergy to Ketamine or Aspirin
• Active Substance Abuse Disorder
• Active Peptic Ulcer Disease

Egyéb

• Adult patients with recent or current suicidal ideation with an intent to act, homicidal ideations with an intent to act
• Patients with unstable vital signs (systolic blood pressure <90 or>160 mm Hg, pulse rate <50 or >150 beats/min, and respiration rate <10 or >30 breaths/min),
• Active psychosis
• Swallowing difficulty
• Consumption of Aspirin or NSAID's within 6 hours of arrival to the site
• Pregnant or breastfeeding

• Adult patients with Treatment Resistant Depression with Montgomery-Asberg Depression Rating Scale score >22 upon presentation to the clinic
• Treatment Resistant Depression is defined as Major Depressive Disorder that does not cease after at least 6 week trial of another class of antidepressants
• Unipolar Depression