REStoring lymphoCytes Using NKTR-255* After chemoradiothErapy in Solid Tumors (RESCUE)

Korábbi kezelés

• Prior diagnosis of hepatitis B or C (unless anti-hepatitis C therapy has produced a sustained virologic response);
• Serious concomitant disorder, including active systemic infection requiring treatment, as judged by the Investigator.
• Known or suspected hypersensitivity to any component of the investigational product
• Recurrent radiation to the treatment site
• Prior major surgery within 4 weeks of enrollment from which the patient has not recovered
• Other condition or prior therapy that, in the opinion of the Investigator, compromises the subject's welfare or may confound study results
• Previous enrollment in this study
• Prior exposure to any anti-PD-1 or anti-PD-L1 antibody.
• Patients with grade 4 toxicities during chemoradiation not resolved to grade ≤ 1 by the end of chemoradiation.
• Prior exposure to IL-2 or IL-5.

Más betegség

• Subjects are to be excluded from the study if any of the following conditions apply:
• HIV infection, cellular immune deficiencies, hypogammaglobulinemia or dysgammaglobulinemia, or hereditary or congenital immunodeficiencies
• History of clinically significant autoimmune disease, Crohn's disease, ulcerative colitis, or inflammatory disease.
• Evidence of clinically significant interstitial lung disease or active noninfectious pneumonitis during the course of chemoradiation that is unresolved to ≤ grade 1.

Laborértékek

• Pregnancy: a female subject defined as a WOCBP who has a positive urine pregnancy test (e.g. within 72 hours) prior to treatment. If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required.

Egyéb

• Patients must be capable of understanding and providing a written informed consent.
• Patients with leukemias or lymphomas with T cell/histiocyte or NK cell rich component(s) and other variants not otherwise specified that contain high numbers of T or NK cells.

• Age 18 years or older
• Histologic diagnosis of non-small cell lung cancer
• Written consent obtained before initiation of any study-related procedures
• Definitive cancer treatment intent
• Absence of concurrent malignancies at other sites, except low risk prostate cancer and basal cell of the skin. Participants with prior cancers should not be receiving active cancer treatment within the past 3 months. Cancer survivors who have undergone potentially curative therapy for a prior malignancy who have no evidence of that disease for 1 year and who are deemed at low risk for recurrence are eligible for the study.
• Adequate liver (AST, ALT, Alk Phos, and Tbili <2 fold upper limit) and kidney function (Cr < 2.5 limit of normal and Cr clearance >30)
• ECOG 0-2