Minimising Adverse Drug Reactions and Verifying Economic Legitimacy in Children (MARVEL-PIC)

Korábbi kezelés

• Duration of the drug of inclusion total treatment length is planned to be less than one week.
• Patient has existing impaired hepatic or renal function for which a lower dose or alternate drug selection are already part of current routine care.

Más betegség

• Patient has advanced liver failure.

Életkor

• Age > 18 years.

Egyéb

• Patient has a life expectancy estimated to be less than three months by the treating clinical team.
• Patient and/or parent is unable to consent to the study.
• Patient and/or parent is unwilling to take part in the study.
• Patient and/or parent is able unable to complete Ped-PRO-CTCAE survey in English, Italian or Chinese.
• Patient has a glomerular filtration rate of less than 15 mL/min per 1.73m2.

• Age < 18 years
• New cancer diagnosis or patient receiving HSCT or patient has a relapsed cancer diagnosis and is starting treatment after more than 6 months without.
• Starting treatment with a chemotherapeutic agent that is not single agent oral targeted therapy.
• Must also be taking a medication for which there is an established CPIC guideline available.
• Parent or patient is able and willing to give consent for patient to take part and be followed up for at least 12 weeks.
• Patient is amenable to venepuncture and blood draw (5mL ideally with an absolute minimum requirement of 2.5 mL) or has Whole Genome Sequencing available (WGS).
• Patient and/or parent is able and willing to sign an informed consent form.
• Patient and/or parent is able to complete Ped-PRO-CTCAE survey in English, Italian or Chinese.
• Study enrolment limit has not been reached.