External Body Pressure in Heart Failure With Preserved Ejection Fraction

A regiszterben nem jelölt feltételek

• Heart Failure Study Population
• Inclusion Criteria (Aim 1 and 2):
  • Age greater than or equal to 30 yrs
  • Established diagnosis of HFpEF with left ventricular ejection fraction greater than or equal to 50%
  • NYHA II-III symptoms
  • Stable HF drug regimen for the preceding 1 month
  • Wedge pressure greater than or equal to 15 mmHg at rest or greater than or equal to 25 mmHg with peak exercise
  • (For Aim 2 only) Scheduled for an elective right heart catheterization at Duke University Hospital.
• Exclusion Criteria (Aim 1 and 2):
  • HF hospitalization for type I myocardial infarction within 3 months
  • Infiltrative (ie amyloid) or hypertrophic cardiomyopathy
  • Uncontrolled atrial or ventricular arrhythmia
  • Chronic oxygen use
  • History of vasovagal syncope
  • Considered inappropriate to participate by PI or Sub-I
  • Healthy Volunteers (Controls)
• Inclusion Criteria (Aim 1):
  • Age greater than or equal to 30 yrs
  • Able to speak English
  • Ambulatory [assistive devices ok]
  • Able to provide informed consent
• Exclusion Criteria (Aim 1):
  • Acute myocardial infarction (3-5 days)
  • Unstable angina
  • Uncontrolled arrhythmia causing symptoms or haemodynamic compromise
  • Syncope
  • Active endocarditis
  • Acute myocarditis or pericarditis
  • Symptomatic severe aortic aneurysm
  • Uncontrolled asthma
  • Arterial desaturation at rest on room air <85%
  • Untreated left main stem coronary stenosis
  • Asymptomatic severe aortic stenosis
  • Severe untreated arterial hypertension at rest (>200 mm Hg systolic, >120 mm Hg diastolic)
  • Tachyarrhythmias or bradyarrhythmias
  • Hypertrophic cardiomyopathy
  • Significant pulmonary hypertension
  • Thrombosis of the lower extremity until treated for a minimum of 2 weeks
  • Within 2 weeks of acute symptomatic pulmonary embolus
  • Abdominal aortic aneurysm >8.0 cm
  • Electrolyte abnormalities
  • Pregnancy
  • Inmate of correctional facility (i.e. prisoner)
  • Diagnosed history of dementia
  • Inability to ambulate independently
  • Considered inappropriate to participate by Principal Investigator