Electrophysiologic Studies of Cognition in Epilepsy Patients

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• Pre-operative neuropsychological testing indicates a Montreal Cognitive Assessment (MOCA) score < 26.
• English language proficiency insufficient to complete psychometric questionnaires and receive task instructions (<6th grade reading level) as determined by neuropsychologist at pre-operative assessment
• Vulnerable populations such as minors, pregnant women, cognitive impaired individuals and prisoners will not be included in the study

• Epileptologists at Mount Sinai West have identified the patient as having drug-resistant epilepsy that may benefit from surgery
• Patient has or will undergo invasive monitoring as part of routine surgical management
• Patient has or will be implanted with a minimum of 6-8 bilateral SEEG pairs, including posterior and anterior insula, and at least four of the following targets:
  • ventral lateral prefrontal cortex
  • dorsal medial prefrontal cortex
  • mid-cingulate
  • subcallosal cingulate
  • amygdala
  • hippocampus
  • fusiform gyrus
• Sufficient use of hands to complete self-report questionnaires and tasks, as determined during pre-surgical neuropsychological assessment
• Normal or corrected to normal vision, determined by patient report
• Use of anti-epileptic drugs (AEDs) with known psychiatric complications will not be an exclusion criterion