Menthol for Dyspnea Relief in Health and COPD

Más betegség

• Contraindication to exercise testing (e.g., significant cardiovascular, musculoskeletal, neurological disease; see Table 4 from ERS/ATS consensus statement)
• Significant pulmonary or extra-pulmonary disease that, based on clinical assessment, could influence dyspnea and/or impair exercise capacity (with the exception of COPD in WP3 and 4)
• An ulcer or tumor in the esophagus, a nasal septum deviation, or recent nasopharyngeal surgery
• Allergies to latex and sensitivities to local anesthetics
• Inability to give informed consent, including those with significant cognitive impairment

Életkor

• History of early menopause (age <45 years)

Egyéb

• Body mass index <18.5 or >35 kg/m2
• Severe facial trauma including cribriform plate disruption (bone separating brain from nasal cavity)
• Alcohol consumption within 12 hours of study visit
• Current smoker*
• Pregnancy or desire to become pregnant while in trial

• Age: 18 years of age or older
• Able to speak, read, and write Dutch or English
• Normal pulmonary function: forced expiratory volume in 1 second (FEV1) to forced vital capacity ratio>0.70; FEV1≥80%predicted (WP1 and 2 only)
• Non-smoker or former smokers (smoke-free ≥12 months prior to enrolment) (WP1 and 2 only)
• Clinically stable COPD (based on clinical judgment of the study physician that have not had exacerbations requiring escalation of medical therapy (i.e., short course of oral corticosteroids or antibiotics) within the preceding 14 days (WP3 and 4 only)