Super Saturated Oxygen (SSO2) Therapy in Patients With ST-segment Elevation Myocardial Infarction (STEMI) and Action on Coronary Microcirculation Dysfunction

Korábbi kezelés

• Previous myocardial infarction
• Use of thrombolytic therapy
• Patients with a contraindication to anticoagulant therapy.
• Gastrointestinal or urogenital bleeding within the last two months or any major surgery (including CABG) within six weeks prior to surgery.

Más betegség

• History of anterior coronary artery bypass grafting (CABG)
• History of PCI on the LAD
• Valvular stenosis or heart failure, pericardial disease, or nonischemic cardiomyopathy.

Laborértékek

• Known prior left ventricular ejection fraction (LVEF) < 40%,
• Creatinine clearance <30 ml/min/1.73 m2,
• Hemoglobin <10 g/dL

Életkor

• Female of childbearing age

Egyéb

• New LAD PCI planned within 30 days.
• Mechanical complications of STEMI (Patients with ventricular pseudoaneurysm, ventricular septal defect (VSD), or severe mitral valve regurgitation (with or without papillary muscle rupture)), cardiogenic shock, or Presence of an intra-aortic counterpulsation balloon.
• Patient on deferral or participating in another clinical investigation,
• Protected populations: pregnant women, parturients, nursing mothers; persons deprived of liberty by a judicial or administrative decision; protected adults

• Age >18 years and <80 years
• ST-segment elevation myocardial infarction within 6 hours of symptom onset with ≥1 mm ST-segment elevation in ≥2 contiguous leads in V1-V4 or new left bundle branch block.
• Successful PCI of a proximal or medial LAD lesion with commercially available coronary stents and achievement of residual stenosis <50% diameter and thrombolysis-in-myocardial-infarction (TIMI) flow grade 2 or 3.
• Systemic arterial pO2 greater than or equal to 10.7 kPa or 80 mmHg with or without oxygen supplementation.
• Patient enrolled in a social security plan or beneficiary of such a plan
• Consent obtained from the patient before inclusion (Emergency consent)