NCT05808504Fut, nem toboroz
Investigation of the Benefits of Electrical Non-invasive Stimulation on Cognitive Symptoms in Parkinson's Disease
Forrás: ClinicalTrials.gov · Utoljára frissítve: 2026. okt. 23.
Rövid összefoglaló (regiszter, angolul)
Parkinson's disease is the second most common neurodegenerative disease after Alzheimer's disease. It is mostly characterized by the presence of motor difficulties. However, it can also be accompanied by cognitive disorders which have an equally significant impact on the quality of life of patients and which are not relieved by any treatment. Among the functions affected by Parkinson's disease, inhibition is an essential process for adapting our behaviors in daily life. Inhibition allows us to stop an action that is no longer required or appropriate to the situation in which we find ourselves in. For example, it comes into play when we have to stop at a "stop" sign while driving. Recent studies suggest that it could be possible to improve the functioning of these processes by using non-invasive brain stimulation tools. Transcranial alternating current electrical stimulation has thus showed promising results in improving functions such as working memory. This technique is completely painless and non-invasive and consists in applying an electric current of very low intensity (barely perceptible) at the level of the scalp, using electrodes. The investigators are conducting a study to test whether transcranial alternating current electrical stimulation could improve the functioning of the inhibition process which is altered in patients. For this, the investigators will measure this process using a task performed on a computer (the Stop Signal Reaction Time Task), as well as brain activity using a method called "electroencephalography", before and after stimulation. For this study, the investigators will include 50 patients and 40 healthy participants to investigate the effect of the stimulation on inhibition.
- Állapot (regiszter)
- Fut, nem toboroz
- Vizsgálattípus
- Beavatkozással járó
- Résztvevők száma
- 90 (tervezett)
- Első benyújtás
- 2023. márc. 13.
- Kezdés
- 2023. máj. 3.
- Elsődleges befejezés
- 2026. márc. 31.
- Fő szponzor
- Institut National de la Santé Et de la Recherche Médicale, France
- Betegségek
- Parkinson-kór
- NCT-szám
- NCT05808504
Mit vállalsz
- Vizsgálat típusa: Beavatkozással járó
- Tervezett résztvevők: 90
- 2023. máj. 3. és az elsődleges befejezés (2026. márc. 31.) között
- 1 helyszín, 1 országban
- Vizitek és vizsgálatok: kérdezd a vizsgálat csapatát, a regiszter nem sorolja fel őket
A(z) ClinicalTrials.gov regisztermezőiből összeállítva. A vizsgálat felépítését írja le.
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Korábbi kezelés
- Drug or alcohol addiction.
Más betegség
- Major cognitive impairment (Moca < 22) or severe neurocognitive disorder according to DSM-V (Diagnostic and statistical manual of mental disorders -V);
- Present or past moderate to severe psychiatric pathology (obsessive compulsive, bipolar disorder, schizophrenia, etc.).
- Present or past neurological pathology other than Parkinson's disease (accident stroke, head trauma, etc.).
Életkor
- Potential for pregnancy or confirmed pregnancy. A pregnancy test will be performed on inclusion.for women of childbearing age.
- Criteria exclusive to patients:
Egyéb
- For all participants:
- Motor difficulties preventing the achievement of the task.
- Adult subject to legal protection (safeguard of justice, curatorship, guardianship), persons deprived of liberty.
- Deep brain stimulation treatment.
- Exclusive to healthy participants:
- Present or past neurological pathology.
Kiket keres a vizsgálat
- For all participants:
- Affiliation to a social security scheme or beneficiary of such a scheme.
- Age over 18 years old.
- Age less than 75 years old
- Correct or correctly corrected view (on simple declaration by the patient).
- Subject having received information on the protocol and having provided informed and written consent to participate.
- Criteria exclusive to patients:
- Idiopathic Parkinson's disease according to United Kingdom Parkinson's criteria Brain Bank disease (Hughes et al., 1992).
Életkor a regiszterben: 18 év – 75 év · Nem: nők és férfiak · Egészséges önkénteseket is fogad
Helyszínek (1)
Helyszínek a regiszter sorrendjében. Ha a profilodba mented a városodat, távolság szerint rendeződnek.
| Helyszín | Város | Ország | Helyszín állapota |
|---|---|---|---|
| CHU de Rennes | Rennes | Franciaország | Ismeretlen állapot |
Ez az oldal tájékoztatás, nem orvosi tanács. Bármely vizsgálatról az orvosoddal beszélj.