Maternal ExeRcIse Timing to Optimise Postprandial Glucose in Type 1 Diabetes

Korábbi kezelés

• Use of any medication (e.g., steroids), that, in the opinion of local clinician/researcher, would negatively impact or mitigate full participation and completion, or could influence the study results.

Más betegség

• Having polycystic ovarian syndrome, poorly controlled asthma/allergy, uncontrolled thyroid diseases or hypertension, diabetic ketoacidosis, hepatitis B, hepatitis C, HIV.
• Having severe autoimmune/immunodeficiency, macrovascular, renal, or neuromuscular disease, or severe retinopathy or neuropathy.
• Having any other cardiovascular, pulmonary, orthopaedic, neurologic, psychiatric, or terminal disease, or any other acute/chronic disorder that, in the opinion of the local clinician/researcher, would preclude participation and successful completion of the protocol, or that would directly influence the study results.
• Any condition that would interfere with compliance or the results, as judged by the Investigator

Laborértékek

• Having poor glycaemic control HbA1c>10% (86 mmol/mol).

Egyéb

• Recurrent severe hypoglycaemia; hospitalisation for diabetic ketoacidosis during the last year.
• Women who smoke or drink alcohol frequently, or require complex diets.
• Pregnant women: having multiple pregnancy
• Pregnant women: evidence of incompetent cervix, ruptured membranes, placenta previa, foetal malformation, or foetal death.

• Pregnant women and non-pregnant women with T1DM aged 20-40 years
• Having a BMI of 18-29.9 kg/m2 at pre-pregnancy (pregnant women) or recruitment (non-pregnant)
• Clinical diagnosis of T1DM, or/and multiple daily insulin injections for >1 year, and/or using insulin pump therapy (open-loop).
• Willingness to provide informed consent to participate in the MERIT1D study.
• Being able to read and speak German, English or Spanish well enough to completely understand the instructions, provide informed consent and conduct the experimental procedures.