NCT05847309Befejeződött
Early vs Delayed Extubation After Endovascular Treatment for Acute Ischemic Stroke
Optimal Ventilation Time After Endovascular Treatment Under General Anesthesia for Acute Ischemic Stroke. A Prospective, Randomized Comparison Between Early vs Delayed Extubation
Forrás: ClinicalTrials.gov · Utoljára frissítve: 2026. márc. 25.
Rövid összefoglaló (regiszter, angolul)
Although older studies, most of them retrospective in design, advocated sedation over general anesthesia during endovascular treatment for acute ischemic stroke, a recent meta-analysis and randomized studies have shown that general anesthesia is associated with better functional status at 3 months compared with local anesthesia and sedation. In our center, most procedures are performed under general anesthesia, and once the procedure is complete, the patient is transferred intubated and sedated to the ICU. If the patient is hemodynamically and respiratory stable, the patient will be extubated, and will be discharged to the Neurology hospitalization floor. Several factors have been described that may influence the evolution and functional status at three months of patients who have suffered a stroke and have received endovascular treatment, such as the time between the onset of symptoms and admission to the ward for performing the procedure, the use of general anesthesia compared to sedation and local anesthesia, adequate control of blood pressure, the size of the cerebral infarct, or a worse neurological examination at the time of the procedure. In turn, several factors have been described that may influence the success of extubation in a patient who has suffered an acute ischemic stroke and who has required orotracheal intubation, such as the absence of dysarthria, the size of the infarct, the location of the infarction, the NIHSS (National Institutes of health Stroke Scale) or neurological status prior to orotracheal intubation. The investigators do not know, however, whether the time of mechanical ventilation can influence the evolution and functional status at three months of patients who have suffered a stroke and have received endovascular treatment under general anesthesia
- Állapot (regiszter)
- Befejeződött
- Vizsgálattípus
- Beavatkozással járó
- Résztvevők száma
- 174 (tényleges)
- Első benyújtás
- 2023. ápr. 14.
- Kezdés
- 2023. ápr. 18.
- Elsődleges befejezés
- 2025. jún. 30.
- Fő szponzor
- Hospital Clinico Universitario de Santiago
- Betegségek
- Stroke (szélütés)
- NCT-szám
- NCT05847309
Mit vállalsz
- Vizsgálat típusa: Beavatkozással járó
- Bevont résztvevők: 174
- 2023. ápr. 18. és az elsődleges befejezés (2025. jún. 30.) között
- 1 helyszín, 1 országban
- Vizitek és vizsgálatok: kérdezd a vizsgálat csapatát, a regiszter nem sorolja fel őket
A(z) ClinicalTrials.gov regisztermezőiből összeállítva. A vizsgálat felépítését írja le.
Ki nem vehet részt
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Korábbi kezelés
- Patients who suffer bronchial aspiration prior to the endovascular procedure or during intubation.
- Patients with functional neurological status, prior to the ischemic stroke, measured with the modified Rankin scale (mRS) of value: 3-6.
Más betegség
- Patients with vascular involvement of the posterior cerebral circulation, or intracranial haemorrhage associated with stroke.
Egyéb
- Patients who have not been intubated in the interventional radiology room.
- Pregnancy
- Patients who underwent the procedure under local anesthesia and sedation.
- Patients who do not sign the informed consent by themselves or their relatives.
Kiket keres a vizsgálat
- Adult (age ≥ 18 years)
- Acute ischemic stroke due to large intracranial vessel occlusion demonstrated on CT-angiography in the following anterior circulation locations (occlusion of the internal carotid artery and/or middle cerebral artery in segments M1, M2, M3) within 24 hours of symptom onset.
- Patients admitted with a NIHSS neurological status ≥ 6.
- Patients who received endovascular treatment under general anesthesia (intubated in the interventional radiology room) with satisfactory reperfusion (TICI 2b-2c-3).
- Patients admitted in the intensive care unit (ICU) with mechanical ventilation.
- Written informed consent from the patient or proxy (if present) before inclusion or once possible when patient has been included in a context of emergency.
Életkor a regiszterben: 18 év – - · Nem: nők és férfiak · Egészséges önkénteseket nem fogad
Helyszínek (1)
Helyszínek a regiszter sorrendjében. Ha a profilodba mented a városodat, távolság szerint rendeződnek.
| Helyszín | Város | Ország | Helyszín állapota |
|---|---|---|---|
| University Clinical Hospital of Santiago de Compostela | Santiago de Compostela | Spanyolország | Ismeretlen állapot |
Kapcsolódó publikációk
- Early vs Delayed Extubation After Thrombectomy for Acute Ischemic Stroke: The EDESTROKE Randomized Clinical Trial.JAMA Neurol · 2026 · PMID 41910960
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