Accelerated rTMS for Post-Stroke Apathy

Korábbi kezelés

• Concomitant neurological disorders affecting motor or cognitive function (e.g. dementia)
• Acute suicidality as assessed by the Columbia Suicide Severity Rating Scale (C-SSRS) or suicide attempt in the previous year

Más betegség

• Primary extra-axial hemorrhage (subdural or subarachnoid) without ischemic stroke or intraparenchymal hemorrhage
• Visual impairment precluding completion of cognitive tasks
• Presence of contraindications to MRI or TMS including electrically, magnetically or mechanically activated metal or nonmetal implants such as cardiac pacemakers, intracerebral vascular clips, or any other electrically sensitive support system;
• History of a seizure disorder
• Active substance use disorder
• Psychotic disorders
• Bipolar 1 Disorder

Egyéb

• Moderate or severe global aphasia
• Pregnancy (to be later confirmed by UPT in any premenopausal female participants)
• Preexisting scalp lesion, wound, bone defect, or hemicraniectomy
• Claustrophobia precluding the ability to undergo an MRI

• 40 years old or greater
• Right- or left-hemisphere ischemic or hemorrhagic stroke with at least 6 months chronicity
• Symptomatic apathy as confirmed by (A) total score on the Apathy Evaluation Scale (AES) of ≥39 as rated by the participant or caregiver informant
• Intact cortex under the coil at the stimulation target site confirmed by neuroimaging
• Ability to participate in psychometric testing and cognitive tasks