Early Metabolic Adaptations to SGLT2 Inhibition in Heart Failure

Korábbi kezelés

• Receiving therapy with an SGLT2 inhibitor within 8 weeks prior to enrollment or previous intolerance to an SGLT2 inhibitor
• Previous cardiac transplantation or implantation of a ventricular assist device
• ANY intracranial implants of any type other than dental fillings
• An intra-luminal implant, filter, stent, or valve replacement

Más betegség

• Acute coronary syndrome or unstable angina within the past month
• Any condition that will interfere with the completion of the study. This may include comorbid conditions or logistical factors that may impede successful completion of the protocol (e.g. inability to travel for follow-up visits)
  • Absolute Exclusions for the Leg MRI Assessment (may still participate in blood sampling and six-minute walk testing):
• ANY personal history of intraocular injury or fragment in or around the orbit that cannot be cleared through radiologic examination
• ANY personal history of bullet, shrapnel, or stabbing wounds that cannot be cleared through radiologic evaluation.
• A cardiac pacemaker or implanted cardiac defibrillator (ICD)##

Egyéb

• Subject inability/unwillingness to perform a six-minute walk test
• ANY non-removable piercings, jewelry, or medicinal patch
• ANY non-removable life assist device, pump, or prosthetic
  • Possible Exclusions** for the Leg MRI Assessment (may still participate in blood sampling and six-minute walk testing):
• A vascular clip or clamp
• A surgically placed clip, clamp or band on visceral organs

• Age ≥18 years
• Clinically diagnosed HF documented in the patient's medical record
• NYHA Class II-III functional status, according to the most recent clinical evaluation
• Availability of an echocardiogram or cardiac MRI within the prior year
• Stable HF medical therapy (no change in beta-blocker, ACE/ARB, ARNI or MRA for at least 4 weeks prior to screening) with the exception of diuretics
• Planned initiation of on-label SGLT2i therapy