Repetitive Versus Deep Transcranial Magnetic Stimulation for Major Depression

Korábbi kezelés

• Having previously received TMS;
• Concomitant major unstable medical or neurological illness
• If participating in psychotherapy, must have been in stable treatment for at least three months before entry into the study, with no anticipation of change
• Currently taking more than the equivalent of 2 mg of lorazepam of a benzodiazepine daily or any dose of an anticonvulsant due to the potential to limit TMS effectiveness

Más betegség

• Substance use disorder within the last three months
• Diagnosis of bipolar or psychosis spectrum disorder
• Anxiety or personality disorder that is assessed by a study investigator to be the primary cause and causing greater impairment than MDD
• Intracranial implant, cardiac pacemaker or implanted medication pump

Laborértékek

• Significant laboratory abnormality;

Egyéb

• Active suicidal intent
• Pregnancy

• Diagnosis of Major Depressive Disorder, at least moderate intensity, single or recurrent episode
• HRSD-17 score of at least 18
• No improvement to at least two adequate courses of antidepressants (based on the ATHF) or were unable to tolerate at least two separate trials of antidepressants of inadequate dose and duration
• On a stable antidepressant regimen for the past four weeks before screening
• Patients with a chronic depressive episode >2 years and who have previously received ECT or ketamine will be eligible to participate