Study of the Glymphatic System in Migraine

Korábbi kezelés

• Overuse of acute medications for headache;
• Any person where MRI scanning is contraindicated (metal implants, pacemaker, claustrophobia, etc.);
• Use of illicit drugs;

Más betegség

• Other primary headache disorders, with the exception of infrequent tension-type headache.
  • For healthy controls:
• Any subject with frequent tension type headache, migraine, cluster headache, other pain syndromes or neurological conditions.
  • For both patients and healthy controls:
• Allergy to nitroglycerin;
• Major psychiatric disorders such as bipolar affective disorder and schizophrenia;
• Cardiovascular diseases that contraindicated the use of nitroglycerin;
• Intracranial hypertension;
• Cerebral haemorrhage;

Egyéb

• For patients:
• Continuous or daily headache;
• Cerebral trauma;
• Pulmonary toxic oedema;
• Closed angle glaucoma;
• Anaemia;
• Pregnancy and breastfeeding;
• Aortic stenosis or significant hypotension (SBP<90mmHg or <100mmHg and symptomatic) precluding nitroglycerin administration;
• Use of sildenafil;
• Any person unable to lie still within the environment of the MRI scanner for the required period to perform the study;
• MRI head showing any brain pathology, such as space-occupying lesions;
• Any person unable to understand and follow the instructions of the investigators.

• For patients:
• Diagnosis of migraine, by the ICHD-3 criteria;
  • For both patients and healthy controls:
• Age between 18 and 60 years;
• Willing and able to comply with scheduled visits.