SIRT for Potentially Resectable HCC

Más betegség

• Decompensated liver function, including ascites, bleeding from esophageal and gastric varices, and/or hepatic encephalopathy
• Organ (heart, kidney) dysfunction
• HBsAg and anti-HCV antibody positive concurrently
• History of malignancy other than HCC
• Uncontrolled infection
• History of HIV
• History of organ and cell transplantation
• Patients with bleeding tendency

Egyéb

• Tumor involving main portal vein, bilateral branches of portal vein, or vena cava
• tumor extention beyond one lobe of the liver
• Bilobar tumor distribution
• Extrahepatic metastasis

• HCC with diagnosis confirmed pathologically or clinically
• No pervious treatment for HCC
• At least one measurable intrahepatic target lesion
• Potentially resectable HCC: tumor(s) confined to the left/right hemiliver, with/without invasion to the unilateral branch of the portal vein and/or hepatic vein
• Disease amenable to SIRT (after evaluation)
• Child-Pugh Class A or without cirrhosis
• Eastern Cooperative Oncology Group performance status (ECOG PS) of 0 or 1
• Patients with active hepatitis B are allowed, but they need to receive antiviral treatment to achieve a HBV DNA<10\^3 IU/mL
• Patients with hepatitis C need to finish the anti-HCV treatment
• Adequate organ and bone marrow function; the blood biochemical examination: platelet count ≥75×10\^9/L, white blood cell count >3.0×10\^9/L, absolute value of neutrophils >1.5×10\^9/L, hemoglobin ≥85 g/L, ASL and AST≤5×ULN, creatinine≤1.5×ULN, INR<1.5 or PT/APTT normal range
• Life expectancy of at least 6 months