NCT06015256Toboroz
Characterization of Natural Killer Cells in Severe Asthma Patients in Comparison With Control Subjects
Characterization of Natural Killer Cells in Severe Asthma Patients in Comparison With Control Subjects: Identification of Biomarkers, Response During Virus-induced Exacerbations, and Interaction With Bronchial Epithelial Cells
Forrás: ClinicalTrials.gov · Utoljára frissítve: 2026. okt. 29.
Rövid összefoglaló (regiszter, angolul)
Asthma is a common chronic bronchial disease affecting 300 million people worldwide. The disease can be severe when it is not managed properly or when it is not controlled by treatments. Asthma is characterized by bronchial inflammation, bronchial hyperreactivity and tissue remodeling. Symptoms include episodes of coughing, dyspnoea and wheezing in relation with bronchial obstruction. The evolution is marked by the occurrence of exacerbations (increase of symptoms), most often triggered by viral infections, mostly due to rhinoviruses. The treatment of asthma is based on inhaled corticosteroid therapy sometimes combined with other treatments that help control the majority of asthma. However, about 10% of patients suffer from persistent symptoms despite these treatments. Natural killer (NK) cells are important actors of the antiviral innate immune response and are present in high numbers in the lungs. However, their role in severe asthma and its virus-induced exacerbations is unknown. The purpose of this work is to characterize NK cells in severe asthma in order to identify molecules expressed differently from control subjects. The goal is to assess whether these molecules could be potential biomarkers of a severe asthma subtype, also known as the endotype, and/or be the molecular control for exacerbation. The advantage of identifying biomarkers for inflammatory diseases lies in their usefulness in establishing a correct diagnosis, monitoring the progress of the disease and the effectiveness of treatments. The secondary objectives are to characterize the activation of NK cells in response to in vitro rhinovirus infection of different types, in monoculture or in a model of interaction with a bronchial epithelium, and identify one or more molecules involved in the interaction between bronchial epithelial cells and NK cells.
- Állapot (regiszter)
- Toboroz
- Vizsgálattípus
- Beavatkozással járó
- Résztvevők száma
- 448 (tervezett)
- Első benyújtás
- 2023. júl. 10.
- Kezdés
- 2023. szept. 7.
- Elsődleges befejezés
- 2028. szept.
- Fő szponzor
- Institut National de la Santé Et de la Recherche Médicale, France
- Betegségek
- Asztma
- NCT-szám
- NCT06015256
Mit vállalsz
- Vizsgálat típusa: Beavatkozással járó
- Tervezett résztvevők: 448
- 2023. szept. 7. és az elsődleges befejezés (2028. szept.) között
- 1 helyszín, 1 országban
- Vizitek és vizsgálatok: kérdezd a vizsgálat csapatát, a regiszter nem sorolja fel őket
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Korábbi kezelés
- Treatment with non-steroidal anti-inflammatory drugs (NSAIDs) or opioids in the 10 days prior to inclusion
- Case patient with asthma:
- \- Coexistence of a chronic inflammatory disease other than asthma
- Case healthy volunteers:
- \- Coexistence of an inflammatory pathology
Egyéb
- Cases asthma controlled, uncontrolled excluding exacerbation, uncontrolled asthma exacerbation, and healthy volunteers:
- Person subject to a legal protection measure
- Vulnerable population: minors, persons under guardianship or trusteeship or persons deprived of their rights to liberty by court order.
- women with a known pregnancy
- Inability or refusal to comply with research requirements
- Active or weaned smoker \> 15 PA
- Cases asthma: Pregnancy during follow-up Cases healthy volunteers: Total IgE level greater than 100 kU/L (measured on the study sample)
Kiket keres a vizsgálat
- Cases asthma controlled, uncontrolled excluding exacerbation, uncontrolled asthma exacerbation, and healthy volunteers:
- Consent form read, understood, approved and signed before any study procedure
- Membership of a social security scheme or beneficiary of such a scheme
- Patient aged over 18
- Cases asthma controlled, uncontrolled excluding exacerbation, uncontrolled exacerbation:
- \- Diagnosis of severe asthma confirmed by a respirologist at an expert centre
- Case asthma controlled:
- \- Asthma control confirmed by a lung specialist from an expert centre
- Case uncontrolled asthma excluding exacerbation:
- \- Uncontrolled asthma confirmed by a lung specialist from an expert centre
- Case uncontrolled asthma with exacerbation:
- \- Current exacerbation
Életkor a regiszterben: 18 év – - · Nem: nők és férfiak · Egészséges önkénteseket is fogad
Helyszínek (1)
Helyszínek a regiszter sorrendjében. Ha a profilodba mented a városodat, távolság szerint rendeződnek.
| Helyszín | Város | Ország | Helyszín állapota |
|---|---|---|---|
| Hôpital NORD - AP-HM, Clinique des bronches, de l'allergie et du sommeil Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát | Marseille | Franciaország | Toboroz |
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