Epidural Stimulation in Multiple Sclerosis

Korábbi kezelés

• Receiving diathermy treatment

Más betegség

• History of chronic and/or treatment resistant urinary tract infection
• Unhealed decubitus ulcer
• Any illness or condition which, based on the research team's assessment, will compromise the patient's ability to comply with the protocol, patient safety, or the validity of the data collected during this study.
• History of coagulopathy or other significant cardiac or medical risk factors for surgery
• Diagnosed with cardiopulmonary dysfunction (e.g., chronic obstructive pulmonary disease, cardiac failure, or heart arrhythmia)
• History of frequent hypotension characterized by light headedness, or loss of consciousness
• History of frequent hypertension characterized by headache, or bradycardia

Egyéb

• Currently a prison inmate, or awaiting trial, related to criminal activity
• Pregnancy at the time of enrollment
• Spasticity (grade of 4) measured bilaterally in two muscle groups using Modified Ashworth Scale (MAS). Muscle groups tested will include bilateral knee flexors, extensors; ankle plantarflexors, dorsiflexors
• Unhealed skeletal fracture
• Active participation in an interventional clinical trial
• Ventilator-dependent respiration
• Untreated clinical diagnosis of depression
• Any active, implanted medical device
• Treatment of chemodenervation and/or neurolysis during the trial, or within 6 months of initiating the trial

• Myelopathy secondary to Progressive MS
• No clinical or radiologic MS relapses for > 5 years
• EDSS score of 6.5 (constant bilateral assistance required to walk about 20 meters without resting) as assessed by a Neurologist with a specialty in MS
• Able to ambulate 10 feet independently with or without gait aid use
• At least 22 years of age
• No changes to spasticity medications or dalfampridine over the last 3 months