SRS for NSCLC With Oligo-residual Intracranial Disease After First-line 3rd Generation EGFR-TKI

Laborértékek

• Patients were unable to receive regular doses of third-generation EGFR inhibitors due to other underlying conditions, viral side effects, economic factors, etc. (e.g., continuous discontinuation for more than 1 week, cumulative discontinuation for more than 2 weeks).

Egyéb

• Poor compliance with the study protocol in the investigator's opinion;
• Patients withdrew their informed consent and requested to withdraw from the study;
• Patients did not follow the protocol for follow-up visits as required by this study.

• Pathologically confirmed non-small cell lung cancer;
• Clinical stage IV (AJCC, 8th edition, 2017);
• EGFR mutations: EGFR L858R, EGFR exon 19 deletion;
• Age ≥18 years;
• KPS score ≥70;
• Brain metastasis at the time of diagnosis;
• Complete baseline imaging assessment of metastatic lesions, including enhanced MRI for brain;
• Receiving first-line treatment with third-generation EGFR inhibitors;
• After 3-6 months of third-generation EGFR inhibitor treatment, imaging review indicates no progression of extracranial lesions, and brain lesions are evaluated by thin-layer (1mm layer) enhanced MRI, meeting the following criteria:
  • No more than 10 remaining brain lesions;
  • The maximum diameter of the remaining brain lesions does not exceed 3cm;
  • At least one remaining brain lesion has a diameter greater than 5mm;
  • After evaluation by the researcher, all remaining brain lesions are suitable for stereotactic radiotherapy.
• Patient informed consent.