dTMS for Subjective Cognitive Decline

Korábbi kezelés

• have a metal plate in their head, except in the mouth (such as an ear implant, implanted brain stimulators, aneurysm clips)
• have an implanted medication pump

Más betegség

• have known increased pressure or a history of increased pressure in their brain, which may increase their risk for having seizures
• have a cardiac pacemaker
• have a significant heart condition
• have current depression or a history of any psychotic disorder, bipolar disorder, eating disorder, obsessive compulsive disorder, post-traumatic stress disorder, or dementia other than AD
• have a history of substance abuse in the last 6 months
• have a history of stroke or other brain lesions
• have a personal history of epilepsy
• have a family history of epilepsy
• have a history of abnormal MRI of the brain
• have unstable medical condition(s)

Egyéb

• have a central venous line
• are a pregnant or breast-feeding woman
• have significant hearing loss requiring use of hearing aids
• have untreated hypo- or hyper-thyroidism
• have TMS contraindications
• regularly use benzodiazepines or other hypnotics within 2 weeks of randomization

• have a family history of late onset sporadic Alzheimer's disease (AD) as defined by having a first degree relative, living or deceased, with a probable or confirmed diagnosis of AD
• have subjective memory decline and concern about memory changes
• score 26 or higher on the Montreal Cognitive Assessment (MoCA)
• are willing to provide informed consent
• are able to follow the treatment schedule
• are stable on medications for 2 months and are not expected to change medication during the entire study period (if they are taking medications)
• have a satisfactory safety screening questionnaire for TMS
• have an informant/study partner who is able to complete study questionnaires regarding the participant