Lithium Long COVID Dose-finding Study

Korábbi kezelés

• Plan to change a psychoactive, steroid or diuretic medication in next 5 weeks.
• History of heart attack or stroke within the previous year.

Más betegség

• Fever or signs of acute infection in last 4 weeks.
• COVID vaccine administered within 4 weeks. No change in any psychoactive or steroid medications for ≥30 days.
• Active medical, psychiatric or social problem that would interfere with completing the study procedures in the opinion of the investigator.

Egyéb

• Daily NSAID use.
• Pregnant or nursing or planning to get pregnant over the next 11 weeks.

• Enrolled from November 2022-July 2023 in lithium long COVID clinical trial at UB.
• Reports bothersome fatigue and/or brain fog while not taking lithium or, reports satisfactory benefit to these symptoms while taking lithium.
• Fatigue Severity Scale (FSS) score ≥28 or Brain Fog Severity Scale (BFSS) score ≥28 at baseline or; FSS <28, BFSS <28 and PGIC at Visit 1 of "much improved" or "very much improved" while taking lithium.
• Did not "respond" to placebo therapy, based on the responder analyses outlined in the Preliminary data section above, defined as a ≥18-point reduction FSS or ≥15-point reduction in BFSS from baseline to the end-of-double-blind study phase while receiving placebo therapy.