Clinical Study of EBV-TCR-T Cells for EBV Infection After Allogenic HSCT

Korábbi kezelés

• Patients with uncontrolled active aGVHD one day before TCR-T cell infusion.
• Anticipated to have other cell therapies in 4 week post TCR-T cell infusion.
• Participated in any other clinical study of drugs and medical devices before 30 days of enrollment.

Más betegség

• Have other malignancies.
• Have relapsed and uncontrolled hematologic malignancies.
• Serologically positive for HIV-Ab or TAP-ab.

Laborértékek

• Patients with severe kidney disease (Cr > 3×normal value), liver damage (TBIL >2.5×upper limit of normal value, ALT and AST > 3×upper limit of normal value) or heart failure (NYHA heart function grade IV) one week before TCR-T cell infusion.

Egyéb

• Anticipated to take immunosuppressive hormones on the day of TCR-T cell infusion.
• Pregnant or lactating women.

• Age 14-75 years, gender unlimited.
• Diagnosed with hematologic malignancies and have undergone allogeneic hematopoietic stem cell transplantation (allo-HSCT), with EBV infection after allo-HSCT.
• Karnofsky Score ≥ 70(age ≥16y) or Lansky Score ≥ 50(age<16y).
• TCR-T cell donor inclusion criteria: 1) Age 8-70 years; 2) Understand and voluntarily sign informed consent and are willing to comply with laboratory tests and other research procedures; 3) ≥ 3/6 HLA match with TCR-T cell recipients enrolled; 4) Lymphocyte count = (0.8~4) × 10\^9/L; 5) Have sufficient venous circulation, without any symptoms that do not allow blood cell isolation.