Esomeprazole and Radiation Induced Esophagitis

Korábbi kezelés

• Patient has prior history of upper gastrointestinal bleeding.
• Patient has known or suspected allergic response and prior adverse drug reaction with proton pump inhibitors.
• Patient is currently on clopidogrel, nelfinavir, rilpivirine, methotrexate, rifampin, digoxin, tacrolimus, or phenytoin as these may have major drug interaction with esomeprazole.
• Patients without concomitant chemoradiotherapy and with estimated maximum dose to esophagus of less than 30 Gy (EQD2).

Más betegség

• Patient has history of gastroesophageal junction or stomach cancer.
• Patient has history of pre-existing severe or very severe dysphagia.
• Patient has history of severe liver disease, acute or subacute systemic lupus erythematosus.
• Patient has history of peptic ulcer disease.
• Patient has a history of thoracic radiotherapy within 2 years of enrollment.

Egyéb

• Patient has interstitial nephritis.

• Patient is ≥ 18 years of age.
• Patient or patient's legal representative is willing and able to provide written informed consent and HIPAA authorization prior to performance of any study related activity.
• Patient is willing and able to comply with scheduled visits and treatment schedules.
• Patient has histopathologically confirmed diagnosis of NSCLC clinical stage III (as per the 8th edition of American Joint Committee on Cancer Staging).
• Patients will receive thoracic radiation with estimated maximum dose to esophagus of at least 30 Gy (EQD2) in combination with concomitant chemotherapy.
• Patient has Eastern Cooperative Oncology Group (ECOG) performance status score of 0 to 2.
• Women of childbearing potential (WOCBP) must have a negative pregnancy test (serum or urine HCG) within 2 weeks of enrollment).
• Double inclusion in any ongoing trial (if the other trial permits) will be allowed.