Catheter Ablation in Atrial Fibrillation Patients With HFpEF (STABLE-SR IV Trial)

Korábbi kezelés

• Prior atrial fibrillation ablation
• Previous cardiac transplantation, complex congenital heart disease, rheumatic heart disease
• Any contraindication for radiofrequency catheter ablation, antiarrhythmic drugs or anticoagulation
• Acute coronary syndrome, cardiac surgery, angioplasty or cerebrovascular accident within 12 weeks before enrollment

Más betegség

• A life expectancy below 2 years due to any non-cardiovascular condition
• Heart failure due to any of the following: known genetic hypertrophic cardiomyopathy, infiltrative cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, constrictive pericarditis, active myocarditis, cardiac tamponade, or uncorrected primary valvular disease
• Any conditions that, in the opinion of the investigator, may render the patient unable to complete the study

Egyéb

• Reversible atrial fibrillation, such as hyperthyroidism or hypokalemia-related atrial fibrillation
• Left atrial size≥ 55 mm
• Severe hepatic and renal dysfunction
• Body mass index> 50 kg/m2
• Female in period of pregnancy or breast-feeding
• Involved in other studies
  • The inclusion and exclusion criteria would be reassessed after run-in period and the cut-off of NT-proBNP would be set as >125 pg/ml under sinus rhythm or >365 pg/ml under AF/atrial flutter (AFL).

• Symptomatic paroxysmal or persistent atrial fibrillation
• CHADS2-VASc score≥ 2
• Conform to the diagnosis of HFpEF
  • NYHA II-IV level;
  • Left ventricular ejection fraction (LVEF)≥ 50%;
  • NT-proBNP≥ 300 pg/mL under sinus rhythm or NT-proBNP≥ 600 pg/mL under atrial fibrillation or flutter;
  • Evidence of left ventricular diastolic dysfunction/raised left ventricular filling pressure on echocardiogram.
• Sign informed consent