GLP-1 Receptor Agonists Post-Bariatric Surgery (GRABS) Pilot Trial

Korábbi kezelés

• Revisional bariatric surgery (prior adjustable gastric band, sleeve gastric, vertical banded gastroplasty).
• Use of medications for type 2 di
• Patient-reported Tobacco, e-cigarette, or smoked marijuana use within 12 months As this would preclude patients from undergoing bariatric surgery.
• Current, diagnosed, or self-reported drug or alcohol abuse that, in the opinion of the investigator, would interfere with the subject's ability to comply with study requirements.

Más betegség

• Diagnosis of type I Diabetes
• Personal history of pancreatitis as determined by history.
• Personal or family history of medullary thyroid cancer by history or multiple endocrine neoplasia syndrome type 2
• Myocardial infarction, unstable angina, stroke, or heart failure (NYHA class II) within 1 year by history.
• History of solid organ transplant.
• History of physician-diagnosed malignancy (other than excised non-melanoma skin cancer) in the past 5 years.
• Current uncontrolled hypertension (systolic >150, diastolic >90) or untreated hyperthyroidism.

Laborértékek

• Hemoglobin A1c > 8.5 in last 3 months.
• Screening creatinine elevation with EGFR < 60 at time of randomization.

Egyéb

• Inability or unwillingness of a subject to give written informed consent or comply with the study protocol.
• Pregnancy by urine testing, current lactation, or plans to become pregnant during the study period.
• Use of systemic glucocorticoids in the past 28 days
• Tobacco use in last 12 months
• Pregnancy
• Prisoners
• Unable or unwilling to follow-up
• Unable to understand English/Spanish

• Subject must be able to understand and provide informed consent.
• BMI > 30 12 months after bariatric surgery.
• Age > 25 and < 65
• Patients undergoing primary Roux-en-Y Gastric Bypass