Validation of Different Diagnostic Modalities in the Detection of Cardiac Amyloidosis Among Patients With "Red Flags"
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Assiut University
- Trial code
- NCT06175858
- Record updated
- 2023. december 19.
- Original description
The study aims to test and compare the diagnostic yield of different diagnostic modalities (speckle tracking echocardiography, CMR, serum and urine protein analysis and bone tracer scintigraphy) in the detection of cardiac amyloidosis among patients with "red flags" suspecting cardiac amyloidosis.Read full original descriptionShow less
The study aims to test and compare the diagnostic yield of different diagnostic modalities (speckle tracking echocardiography, CMR, serum and urine protein analysis and bone tracer scintigraphy) in the detection of cardiac amyloidosis among patients with "red flags" suspecting cardiac amyloidosis.
Inclusion: "Red flags" include any one of the following:; Clinical "Red flags":; Bilateral carpal tunnel syndrome (30); "Popeye sign", rupture of long head of the biceps tendon; Lumbar spinal canal stenosis in association with unilateral carpal tunnel syndrome (31); Echocardiographic/imaging "Red Flags"; LV wall thickness ≥ 12 mm and heart failure in men > 60 y/ women > 70y; LV wall thickness ≥ 12 mm and AV-Block or pacemaker; Infiltrative phenotype (biventricular hypertrophy, thickening of cardiac valves, pericardial effusion, thickening of the interatrial septum); LV wall thickness ≥ 12 mm and low voltage on ECG; Paradoxical low flow/low gradient aortic stenosis.
Exclusion: 1. Patient who refuse to give a consent to the following investigations. 2. Patient with any contra-indication to undergo CMR, or bone scintigraphy will be excluded e.g., non compatible implantable cardiac devices, claustrophobic, severe kidney function impairment; Patient with established diagnosis of other infiltrative cardiac disease.