Bace1as Role in Heart Failure (BACE1AS-HF)

Korábbi kezelés

• Subjects undergoing chemo/radiotherapy
• Subjects undergoing prolonged steroid therapy
• Previous cardiac surgery including coronary artery bypass grafting
• Any contraindication to implantation of drug-eluting stents (DES)
• Patients with previous documented myocardial infarction;
• Presence of ACS, stroke, transient ischemic attack, major cardiovascular surgery, percutaneous coronary angioplasty or carotid angioplasty in the previous 3 months;

Más betegség

• Patients with genetic diseases
• Patients suffering from malignant neoplasm
• Subjects with known active infectious diseases
• Subjects with positive serology for HIV, HBV (not vaccinated), HCV.
• Severe heart valve disease or other conditions requiring cardiac surgery
• Patients with known hypersensitivity or contraindication to any of the following drugs:
  • heparin aspirin, clopidogrel, ticlopidine, sirolimus, everolimus.
• Patients suffering from malignant neoplasms or systemic pathologies with a quoad vitam prognosis of less than 1 year;
• Patients suffering from known active infectious diseases;
• End-stage renal disease;
• Patients undergoing cardiac transplantation or on the active list for cardiac transplantation or undergoing LVAD implantation;
• Presence of hemodynamically significant mitral or aortic valve disease except mitral insufficiency due to ventricular dilatation;

Laborértékek

• LVEF <30% before PCI
• Patients with known previous cardiomyopathy with LVEF < 40%

Egyéb

• ESVI <35 ml/m2
• EF>40%
• Tempo from E unknown
• Pregnant women
• Subjects with collagenopathies
• Patients with ACS and left ventricular dysfunction 12 months after percutaneous angioplasty
• Total chronic occlusions
• Patients in cardiogenic shock
• Patients with advanced STEMI (> 48 h from the onset of symptoms/Q waves on ECG) or undergoing fibrinolysis;
• Patients who are unable to express valid informed consent at the time of enrollment
• Pregnant women
• Patients with chronic post-ischemic HF ( recruitment at the Istituti Clinici Scientifici Maugeri Pavia)
• Denial of informed consent;

• left ventricular reconstruction surgery (SVR)
• ESVI >35 ml/m2
• EF<40%
• previous anterior transmural infarction
• age 40-75 years
• Age >18 years
• Patients with ACS (first episode), defined according to the ESC 2017 guidelines [19]
• Informed consent to enrollment in the study
• All patients admitted to Rehabilitation Cardiology at the Cardiology Department of ICS Maugeri with a diagnosis of chronic heart failure on an ischemic or "acute" basis due to exacerbation of chronic heart failure due to previous ischemia and whose therapies have been optimized at the moment of enlistment.
• NYHA Class II-III at the time of enlistment;
• Age over 18 years;
• Informed consent signed at the time of enrollment in the study.

A regiszterben nem jelölt feltételek

• Left ventricular biopsies from patients with post-ischemic HF