mFOLFIRINOX Plus Radiotherapy to Patients With CA19-9-normal Advanced Pancreatic Cancer Refractory to Chemotherapy
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Where in Kína
- Shanghai · Shanghai Cancer CenterTaking people
The registry text, word for word
The purpose of this study is to evaluate the efficacy of mFOLFIRINOX plus radiotherapy to Patients with CA19-9-normal Advanced Pancreatic Cancer refractory to chemotherapy.
Inclusion: Ability to understand and the willingness to sign a written informed consent document; Age ≥ 18 years and ≤ 80 years; Eastern Cooperative Oncology Group (ECOG) performance status 0-2; Histologically or cytologically confirmed advanced pancreas adenocarcinoma; Patients who are refractory to at least one line of chemotherapy and who have not received radiotherapy; Locally advanced or distant metastatic pancreatic cancer; Baseline serum CA19-9 ≤ 37 U/mL, CEA≤ 5.2 ng/mL, and CA125 ≤ 35 U/mL; Presence of at least of one measurable lesion in agreement to RECIST criteria; The expected survival ≥ 3 months; Adequate organ performance based on laboratory blood tests; Women of childbearing potential and men must agree to use adequate contraception prior to study entry and for the duration of study participation.
Exclusion: Primary pancreatic cancer; Severe and uncontrollable accompanying diseases that may affect protocol compliance or interfere with the interpretation of results; Renal insufficiency or dialysis; Other serious accompanying illnesses, which, in the researcher's opinion, could seriously adversely affect the safety of the treatment; Patients who are allergic to oxaplatin or other chemotherapy drugs; Baseline serum CA19-9 > 37 U/mL, CEA > 5.2 ng/mL, or CA125 > 35 U/mL; Pregnant or nursing women; The diagnosis was confirmed by pathology as non-adenocarcinoma of pancreas; Inflammation of the digestive tract, including pancreatitis, cholecystitis, cholangitis, etc; Patients who are unwilling or unable to comply with study procedures.