TYK2 Inhibition in Paradoxical Psoriasis

Korábbi kezelés

• Use of any other anti-psoriatic therapy. Certain washout periods of treatments needs to be respected
• Infection(s) requiring treatment with intravenous (IV) anti-infectives within 30 days prior to the Baseline visit or oral anti-infectives within 14 days prior to the Baseline visit;
• Live vaccine within 12 weeks before Baseline Visit.

Más betegség

• A positive serology test for hepatitis B, hepatitis C, HIV;
• History of lymphoproliferative disease or of malignancy within the past 5 years.
• Chronic recurring bacterial infections or active tuberculosis;
• History of clinically significant alcohol or drug abuse in the last 12 months
• Known hypersensitivity to Deucravacitinib or any of its excipients
• Current severe progressive or uncontrolled disease

Egyéb

• Positive pregnancy test at Screening and at the Baseline visit;
• Female subjects who are pregnant or breast-feeding or considering becoming pregnant during the study;

• Clinical diagnosis of Paradoxical Psoriasis caused by anti-TNF treatment, with with Investigator Global Assessment ≥ 2 and Body Surface Area ≥ 2%
• Females who are of child-bearing potential should be practicing highly-effective contraception methods throughout the study and for 28 days after the last dose of study drug;
• Male subjects with a mechanical contraceptive method;
• be in good health
• be willing to have skin biopsies taken