Pembrolizumab Combined With Preoperative Chemotherapy (Albumin Paclitaxel+Carboplatin) Neoadjuvant Therapy for Resectable Locally Advanced (Stage II/III) Esophageal Squamous Cell Carcinoma

Korábbi kezelés

• Individuals who have received previous treatment for esophageal cancer (surgery, radiotherapy, chemotherapy, immunotherapy, targeted therapy, etc.);
• Not suitable for surgery or with surgical contraindications;
• Individuals with immunodeficiency or long-term systemic steroid therapy, or those who have received any immunosuppressive therapy within 7 days prior to receiving the study drug;
• The surgical procedure violates the plan;

Más betegség

• Have a history of other anti PD-L1/PD-1 treatments;
• Individuals with active autoimmune diseases requiring systemic treatment within 2 years;
• Patients with poor control of heart disease
• For patients with drug allergies in the protocol.
  • Exit criteria：
  • Withdrawal cases refer to subjects who have stopped continuing treatment in clinical research due to various reasons. Subjects who experience the following situations will withdraw from the investigational treatment:
• Patients who fail to undergo non-surgical treatment due to various reasons, including malignant tumor progression, underlying disease progression, patient or their trustee requesting withdrawal, will be reported together;

Egyéb

• Pregnant or lactating female patients;
• The main indicators are missing, and more than half of the items that can be filled in CRF are missing;
• Cases that are excluded due to adverse reactions are not evaluated for efficacy, but side effects should be included in the statistics;
• According to the researcher's opinion, continuing to participate in the study will be harmful to their health;
• Missing subjects. All subjects who withdrew from the study should record their reasons for withdrawal in the CRF and their medical records. According to the ITT principle, all withdrawn cases should undergo survival analysis and toxicity evaluation for the corresponding group.

• Baseline stage resectable cII/III esophageal squamous cell carcinoma (8th UICC TNM stage);
• Failure to receive anti-tumor treatment for esophageal squamous cell carcinoma;
• Age range from 18 to 75 years old;
• There are no surgical contraindications in the preoperative evaluation of various organ functions;
• The following laboratory tests confirm that the bone marrow, liver and kidney functions meet the requirements for participating in the study: hemoglobin ≥ 9.0g/L; White blood cell count 4.0-10 × 109/L; Neutrophil absolute value (ANC) ≥ 1.5 × 109/L; Platelet count ≥ 100 × 109/L; Total bilirubin ≤ 1.5 times the upper limit of normal value; ALT and AST ≤ 2.5 times the upper limit of normal values; The international standardized ratio of prothrombin time is ≤ 1.5 times the upper limit of normal values, and some prothrombin time is within the normal range; Creatinine ≤ 1.5 times the upper limit of normal value;
• Patients who have not undergone chemotherapy, radiation therapy, or hormone therapy for malignant tumors, have no history of other malignant tumors, and do not include prostate cancer patients who have received hormone therapy and have obtained DFS for more than 5 years;
• Expected to achieve R0 resection;
• Physical state ECOG 0-1;
• The subjects must understand and sign the informed consent form